Developmental regulation of microtubule‐based trafficking and anchoring of axonal mitochondria in health and diseases
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22748
Abstract: Mitochondria are cellular power plants that supply most of the ATP required in the brain to power neuronal growth, function, and regeneration. Given their extremely polarized structures and extended long axons, neurons face an exceptional… read more here.
Keywords: microtubule based; based trafficking; trafficking anchoring; anchoring axonal ... See more keywords
Come and eat: mitochondrial transport guides mitophagy in ischemic neuronal axons
Sign Up to like & getrecommendations! Published in 2019 at "Autophagy"
DOI: 10.1080/15548627.2019.1618099
Abstract: ABSTRACT Mitophagy is the sole mechanism for neurons to eliminate superfluous or damaged mitochondria. Although the critical implications of mitophagy have been emphasized in a variety of neurological disorders, it remains ambiguous how neurons control… read more here.
Keywords: transport; come eat; eat mitochondrial; axonal mitochondria ... See more keywords
Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.852245
Abstract: Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform. Indirubin and cantharidin increased… read more here.
Keywords: axonal mitochondria; transport axonal; protein phosphatase; mitochondrial motility ... See more keywords