Complementary research models and methods to study axonal regeneration in the vertebrate retinofugal system
Sign Up to like & getrecommendations! Published in 2017 at "Brain Structure and Function"
DOI: 10.1007/s00429-017-1571-3
Abstract: Due to the lack of axonal regeneration, age-related deterioration in the central nervous system (CNS) poses a significant burden on the wellbeing of a growing number of elderly. To overcome this regenerative failure and to… read more here.
Keywords: research; regeneration; retinofugal system; models methods ... See more keywords
Lentivirus-Mediated Overexpression of miR-29a Promotes Axonal Regeneration and Functional Recovery in Experimental Spinal Cord Injury via PI3K/Akt/mTOR Pathway
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2625-5
Abstract: MicroRNAs as a novel class of endogenous small non-coding RNAs, modulate negative gene expression at the post-transcriptional level. Our previous work has demonstrated that miR-29a reduces PTEN expression by directly targeting the 3′-UTRs (untranslated regions)… read more here.
Keywords: recovery; axonal regeneration; expression; mir 29a ... See more keywords
Epidermal innervation as a tool to study human axonal regeneration and disease progression
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2016.06.016
Abstract: HighlightsAnimal models of axonal regeneration have not translated well to human studies.Epidermal nerve is attractive to directly study axonal regeneration in human subjects.Regenerative and collateral sprouting can be efficiently measured in human skin. read more here.
Keywords: innervation tool; study human; regeneration; axonal regeneration ... See more keywords
Primary culture of mouse embryonic spinal cord neurons: cell composition and suitability for axonal regeneration studies
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2019.1567508
Abstract: Abstract Objective: Primary culture is an effective experimental model to study molecular mechanisms that drive axonal regeneration after central nervous system injury. However, the culture of spinal cord (SC) cells remains poorly characterized. Here, we… read more here.
Keywords: cell composition; axonal regeneration; culture mouse; culture ... See more keywords
Neuroinflammation and Optic Nerve Regeneration: Where Do We Stand in Elucidating Underlying Cellular and Molecular Players?
Sign Up to like & getrecommendations! Published in 2019 at "Current Eye Research"
DOI: 10.1080/02713683.2019.1669664
Abstract: ABSTRACT Neurodegenerative diseases and central nervous system (CNS) trauma are highly irreversible, in part because adult mammals lack a robust regenerative capacity. A multifactorial problem underlies the limited axonal regeneration potential. Strikingly, neuroinflammation seems able… read more here.
Keywords: neuroinflammation optic; regeneration; optic nerve; axonal regeneration ... See more keywords
Systemic Transplantation of Bone Marrow Mononuclear Cells Promotes Axonal Regeneration and Analgesia in a Model of Wallerian Degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Transplantation"
DOI: 10.1097/tp.0000000000001478
Abstract: Background Reinnervation timing after nerve injury is critical for favorable axonal regeneration, remyelination, and clinical improvement. Considering bone marrow mononuclear cells (BMMC) are easily obtained and readily available for transplant, this work analyzed the effect… read more here.
Keywords: mononuclear cells; bmmc; marrow mononuclear; axonal regeneration ... See more keywords
Inhibition of miR-221-3p promotes axonal regeneration and repair of primary sensory neurons via regulating p27 expression
Sign Up to like & getrecommendations! Published in 2023 at "NeuroReport"
DOI: 10.1097/wnr.0000000000001912
Abstract: This study aimed to explore the key microRNA (miRNA) playing a vital role in axonal regeneration with a hostile microenvironment after spinal cord injury. Based on the theory that sciatic nerve conditioning injury (SNCI) could… read more here.
Keywords: regeneration; p27; axonal regeneration; inhibition mir ... See more keywords
The Optic Nerve Crush Injury Paradigm in African Turquoise Killifish to Study Axonal Regeneration in an Aged Environment.
Sign Up to like & getrecommendations! Published in 2023 at "Cold Spring Harbor protocols"
DOI: 10.1101/pdb.prot107828
Abstract: In our graying world population, we are increasingly facing brain injuries and age-associated neurodegenerative diseases, which are often characterized by axonal pathology. Here, we propose the killifish visual/retinotectal system as a model for investigating central… read more here.
Keywords: regeneration; injury paradigm; axonal regeneration; optic nerve ... See more keywords
The Mechanisms of Peripheral Nerve Preconditioning Injury on Promoting Axonal Regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Neural Plasticity"
DOI: 10.1155/2021/6648004
Abstract: Two major factors contribute to the failure of axonal regrowth in the central nervous system (CNS), namely, the neuronal intrinsic regenerative capacity and the extrinsic local inhibitory microenvironments. However, a preconditioning peripheral nerve lesion could… read more here.
Keywords: preconditioning injury; regeneration; axonal regeneration; peripheral nerve ... See more keywords
Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
Sign Up to like & getrecommendations! Published in 2023 at "Mediators of Inflammation"
DOI: 10.1155/2023/5604103
Abstract: Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and… read more here.
Keywords: dose taxol; taxol; axonal regeneration; low dose ... See more keywords
Diapause induces functional axonal regeneration after necrotic insult in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007863
Abstract: Many neurons are unable to regenerate after damage. The ability to regenerate after an insult depends on life stage, neuronal subtype, intrinsic and extrinsic factors. C. elegans is a powerful model to test the genetic… read more here.
Keywords: functional axonal; regeneration; axonal regeneration; insult ... See more keywords