Retrograde Axonal Transport of Neurotrophins in Basal Forebrain Cholinergic Neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1990-2_13
Abstract: Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due to their extremely long and diffuse axonal projections. These neurons are critical… read more here.
Keywords: transport; axonal transport; biology; cholinergic neurons ... See more keywords
Use of Microfluidics Chambers to Image Axonal transport in Adult Sensory Neurons.
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DOI: 10.1007/978-1-0716-1990-2_14
Abstract: Transport of cargoes along axons is crucial for ensuring effective neuronal function and survival. Lysosomes, which are membrane-bound organelles responsible for the degradation of macromolecules, are among the many cargoes being transported. Compartmentalized systems that… read more here.
Keywords: adult sensory; sensory neurons; transport; axonal transport ... See more keywords
Dissection and Direct Imaging of Axonal Transport in Drosophila Segmental Nerves.
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DOI: 10.1007/978-1-0716-1990-2_19
Abstract: For neurons, especially those with long axons, the forceful transport of mitochondria, vesicles, and other cytoplasmic components by cytoskeletal motors is vital. Defects in cytoplasmic transport machinery cause a degradation of signaling capacity that is… read more here.
Keywords: transport drosophila; transport; axonal transport; imaging axonal ... See more keywords
Live Imaging and Quantitative Analysis of Organelle Transport in Sensory Neurons of Aplysia Californica.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1990-2_2
Abstract: Axonal transport moves proteins, RNAs, and organelles between the soma and synapses to support synaptic function and activity-dependent changes in synaptic strength. This transport is impaired in several neurodegenerative disorders such as Alzheimer's disease. Thus,… read more here.
Keywords: aplysia californica; sensory neurons; transport; axonal transport ... See more keywords
Imaging Axonal Transport in Ex Vivo Central and Peripheral Nerves.
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DOI: 10.1007/978-1-0716-1990-2_4
Abstract: Neurones are highly polarized cells with extensive axonal projections that rely on transport of proteins, RNAs, and organelles in a bidirectional manner to remain healthy. This process, known as axonal transport, can be imaged in… read more here.
Keywords: central peripheral; transport; axonal transport; vivo central ... See more keywords
Tau and Axonal Transport Misregulation in Tauopathies.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-32-9358-8_7
Abstract: Tau is a microtubule-associated protein that is involved in both normal and pathological processes in neurons. Since the discovery and characterization of tau over 40 years ago, our understanding of tau's normal functions and toxic roles… read more here.
Keywords: fast axonal; axonal transport; transport; tau axonal ... See more keywords
Possible Mechanisms of Axonal Transport Disturbances in Mouse Spinal Motoneurons Induced by Hypogravity.
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-020-05048-5
Abstract: The data obtained by transcriptome analysis of lumbar spinal cord segments, sciatic nerve, and the respiratory diaphragm of the mice performed after a space flight on board Bion-M1 biosatellite were processed by bioinformatic methods aimed… read more here.
Keywords: transport disturbances; possible mechanisms; motor; hypogravity ... See more keywords
Impairment of Axonal Transport in Diabetes: Focus on the Putative Mechanisms Underlying Peripheral and Central Neuropathies
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1227-1
Abstract: Diabetes mellitus is a chronic disease with numerous complications that severely impact on the quality of life of patients. Different neuropathies may arise as complications associated with the nervous system, both peripherally and at the… read more here.
Keywords: diabetes focus; impairment axonal; transport; transport diabetes ... See more keywords
p27Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.04.083
Abstract: The protein p27Kip1 plays roles that extend beyond cell-cycle regulation during cerebral cortex development, such as the regulation of neuronal migration and neurite branching via signaling pathways that converge on the actin and microtubule cytoskeletons.… read more here.
Keywords: tubulin acetyltransferase; transport; p27kip1; p27kip1 modulates ... See more keywords
A cAMP/PKA/Kinesin-1 Axis Promotes the Axonal Transport of Mitochondria in Aging Drosophila Neurons
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.02.048
Abstract: Summary Mitochondria play fundamental roles within cells, including energy provision, calcium homeostasis, and the regulation of apoptosis. The transport of mitochondria by microtubule-based motors is critical for neuronal structure and function. This process allows local… read more here.
Keywords: promotes axonal; transport; transport mitochondria; camp pka ... See more keywords
Lithium reverses behavioral and axonal transport-related changes associated with ANK3 bipolar disorder gene disruption
Sign Up to like & getrecommendations! Published in 2017 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.01.001
Abstract: Ankyrin 3 (ANK3) has been implicated as a genetic risk factor for bipolar disorder (BD), however the resulting pathophysiological and treatment implications remain elusive. In a preclinical systems biological approach, we aimed to characterize the… read more here.
Keywords: related behavior; transport; lithium; bipolar disorder ... See more keywords