mRNA m5C Alteration in Azacitidine Demethylation Treatment of Acute Myeloid Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23864
Abstract: The DNA demethylating therapy with azacitidine (AZA) is a promising therapeutic strategy for elderly patients with acute myeloid leukemia (AML). AZA primarily inhibits DNA methylation, promotes cell differentiation and apoptosis in AML. However, as a… read more here.
Keywords: aza; acute myeloid; m5c; mrna m5c ... See more keywords
Coombs’ test positive autoimmune hemolytic anemia accompanied by myelodysplastic syndrome that became Coombs’ test negative after azacitidine administration
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Hematology"
DOI: 10.1007/s00277-021-04652-3
Abstract: Myelodysplastic syndromes (MDS) are a group of clonal bone marrow neoplasms characterized by ineffective hematopoiesis, manifesting as morphologic dysplasia in hematopoietic cells and peripheral cytopenia(s) [1]. Autoimmune hemolytic anemia (AIHA) is an autoimmune disease (AD)… read more here.
Keywords: administration; coombs test; cycle; test positive ... See more keywords
Distinct dual antiviral mechanism that enhances hepatitis B virus mutagenesis and reduces viral DNA synthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral research"
DOI: 10.1016/j.antiviral.2019.104540
Abstract: Reverse transcriptase (RT) is an essential enzyme for the replication of retroviruses and hepadnaviruses. Current therapies do not eliminate the intracellular viral replication intermediate termed covalently closed circular (ccc) DNA, which has enhanced interest in… read more here.
Keywords: dna synthesis; mutagenesis; dna; aza ... See more keywords
Diversity, distribution, and azaspiracids of Amphidomataceae (Dinophyceae) along the Norwegian coast.
Sign Up to like & getrecommendations! Published in 2018 at "Harmful algae"
DOI: 10.1016/j.hal.2018.08.011
Abstract: Azaspiracids (AZA) are a group of lipophilic polyether compounds which have been implicated in shellfish poisoning incidents around Europe. They are produced by a few species of the dinophycean genera Azadinium and Amphidoma (Amphidomataceae). The… read more here.
Keywords: presence; microscopy; along norwegian; aza ... See more keywords
Lactoferrin-phenothiazine dye interactions: Thermodynamic and kinetic approach.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.06.097
Abstract: Life manifestation is mainly based on biopolymer-ligand molecular recognition; therefore, the elucidation of energy and speed associated with protein-ligand binding is strategic in understanding and modulating biological systems. In this study, the interactions between methylene… read more here.
Keywords: dye; aza aza; aza; blf ... See more keywords
Adamantyl aziridines via aza-Michael initiated ring closure (aza-MIRC) reaction
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.01.006
Abstract: Abstract An efficient one-pot synthesis of functionalized adamantylaziridines by aza-Michael initiated ring closure (aza-MIRC) reaction of 1-aminoadamantane with α-halogenated Michael acceptors is described. The reaction goes through an aza-Michael intermediate that undergoes an intramolecular nucleophilic… read more here.
Keywords: initiated ring; ring closure; aza; reaction ... See more keywords
Intestinal absorption and tissue distribution of aza-sugars from mulberry leaves and evaluation of their transport by sugar transporters.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c03005
Abstract: Mulberry leaves are rich in aza-sugars, particularly 1-deoxynojirimycin (DNJ), fagomine, and 2-O-α-D-galactopyranosyl-1-deoxynojirimycin (GAL-DNJ), which have anti-diabetes and anti-obesity properties. To help us understand the mechanisms of action of aza-sugars, pharmacokinetic studies are necessary. Therefore, in… read more here.
Keywords: absorption; aza sugars; transport; aza ... See more keywords
WazaGaY: An Innovative Aza-BODIPY-Derived Near-Infrared Fluorescent Probe for Enhanced Tumor Imaging.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.4c01435
Abstract: Aza-BODIPYs represent a class of fluorophores in which the π-conjugated system is rigidified and stabilized by a boron atom. A promising strategy to enhance their fluorescence properties involves replacing the boron atom with a metal… read more here.
Keywords: aza; bodipy derived; tumor; aza bodipy ... See more keywords
Functionalized Tetrahydropyridines by Enantioselective Phosphine-Catalyzed Aza-[4 + 2] Cycloaddition of N-Sulfonyl-1-aza-1,3-dienes with Vinyl Ketones.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.7b00489
Abstract: The development of electron-demand disfavored [4 + 2] cycloaddition of two electron-deficient reacting partners poses a considerable challenge. An enantioselective aza-[4 + 2] cycloaddition of electron-deficient N-sulfonyl-1-aza-1,3-dienes is possible with vinyl ketones via phosphine catalysis,… read more here.
Keywords: cycloaddition; aza cycloaddition; vinyl ketones; sulfonyl aza ... See more keywords
Purification-Free Bortezomib-Drug Conjugates Optimize Drug Economy and Cancer Therapeutic Synergy.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c02160
Abstract: As a promising candidate in overcoming resistance, providing synergy, and developing treatments, conjugated combination drugs mostly prevail over drug cocktails in establishing prodrugs and precisely codelivering multiple drugs for combination chemotherapies. However, current drug-drug conjugation… read more here.
Keywords: aza; economy; purification free; drug ... See more keywords
Frustrated Lewis Pair (FLP)-Catalyzed Hydrogenation of Aza-Morita–Baylis–Hillman Adducts and Sequential Organo-FLP Catalysis
Sign Up to like & getrecommendations! Published in 2017 at "ACS Catalysis"
DOI: 10.1021/acscatal.7b03077
Abstract: Herein we report the metal-free diastereoselective frustrated Lewis pair (FLP)-catalyzed hydrogenation of aza-Morita–Baylis–Hillman (aza-MBH) adducts, accessing a diverse range of stereodefined β-amino acid derivatives in excellent isolated yields (28 examples, 89% average yield, up to… read more here.
Keywords: pair flp; lewis pair; hydrogenation; catalysis ... See more keywords