Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides
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DOI: 10.1039/d1sc04638a
Abstract: Methyl groups can have profound effects in drug discovery but the underlying mechanisms are diverse and incompletely understood. Here we report the stereospecific effect of a single, solvent-exposed methyl group in bicyclic [4.3.1] aza-amides, robustly… read more here.
Keywords: water; aza amides; group bicyclic; methyl group ... See more keywords