Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines
Sign Up to like & getrecommendations! Published in 2018 at "ChemistryOpen"
DOI: 10.1002/open.201800029
Abstract: Abstract Curcumin, a natural compound extracted from the rhizomes of Curcuma longa, displays pronounced anticancer properties but lacks good bioavailability and stability. In a previous study, we initiated structure modification of the curcumin scaffold by… read more here.
Keywords: synthesis novel; curcuminoids improved; novel aza; aza aromatic ... See more keywords
Copper-Catalyzed Functionalization of Aza-Aromatic Rings with Fluoroalcohols via Direct C(sp2)-H/C(sp3)-H Coupling Reactions.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c00797
Abstract: An efficient copper-catalyzed direct C(sp2)-H/C(sp3)-H coupling reaction of aza-aromatic rings with fluoroalcohols is developed. A variety of useful building blocks including hydroxyfluoroalkylated aniline, pyrrole, and indole derivatives bearing a quaternary carbon center could be constructed… read more here.
Keywords: sp2 sp3; sp3 coupling; aromatic rings; direct sp2 ... See more keywords