Enantioselective Total Synthesis of (+)-Stephadiamine through Bioinspired Aza-Benzilic Acid Type Rearrangement.
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DOI: 10.1021/jacs.1c00047
Abstract: We report the first enantioselective total syntheses of the hasubanan alkaloid (-)-metaphanine and the norhasubanan alkaloid (+)-stephadiamine. Key features of these syntheses include diastereoselective oxidative phenolic coupling reaction and subsequent regioselective intramolecular aza-Michael reaction, which… read more here.
Keywords: benzilic acid; type rearrangement; aza benzilic; enantioselective total ... See more keywords