C2-substituted 8-aza-7-deaza-2'-deoxyadenosines as environmentally sensitive fluorescent nucleosides for discriminating apurinic/apyrimidinic sites in DNA duplex
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2016.11.029
Abstract: Abstract We synthesized various C2-naphthylethynylated 8-aza-7-deaza-2′-deoxyadenosines 1a – 1c as novel environmentally sensitive fluorescent (ESF) purine nucleosides. In particular, the N,N -dimethylamino-substituted derivative 1c exhibits a remarkably high solvatochromicity (Δ λ = 111 nm). 1c -containing oligodeoxynucleotide… read more here.
Keywords: sensitive fluorescent; aza deaza; environmentally sensitive; apurinic apyrimidinic ... See more keywords
Synthesis of New 5′-Norcarbocyclic Aza/Deaza Purine Fleximers - Noncompetitive Inhibitors of E.coli Purine Nucleoside Phosphorylase
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DOI: 10.3389/fchem.2022.867587
Abstract: A new series of flexible 5′-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure. The compounds were evaluated as potential inhibitors of E. coli purine… read more here.
Keywords: norcarbocyclic aza; aza deaza; coli purine; deaza purine ... See more keywords