Loss of PTEN sensitizes head and neck squamous cell carcinoma to 5-AZA-2'-deoxycytidine.
Sign Up to like & getrecommendations! Published in 2020 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2020.05.001
Abstract: OBJECTIVE Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer associated with poor survival. Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene involved in the maintenance of stem cells. DNA methylation… read more here.
Keywords: neck squamous; pten; cell carcinoma; squamous cell ... See more keywords
Abstract B26: Combinational effect of sulforaphane (SFN) and epigenetic demethylation agent 5-aza-2’-deoxycytidine (DAC) on metastatic melanoma
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.mel2019-b26
Abstract: UV exposure-induced oxidative stress is implicated as the driving mechanism of melanoma development. Increased oxidative stress results in imbalanced reactive oxygen species (ROS) that damage DNA and dysregulated epigenetic modifications and leads to melanoma progression.… read more here.
Keywords: deoxycytidine dac; melanoma; aza deoxycytidine; sulforaphane sfn ... See more keywords
Effects of 5-aza-2´-deoxycytidine on biological parameters of Achroia grisella F. (Lepidoptera: Pyralidae)
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Biological Sciences"
DOI: 10.2298/abs170622034s
Abstract: The non-target effects of 5-aza-2´-deoxycytidine (5-aza-dC), an epigenetically effective agent, were assessed on different life-history traits of two successive generations of Achroia grisella F. (Lepidoptera: Pyralidae) by trophic exposure. The results did not reveal any… read more here.
Keywords: aza deoxycytidine; lepidoptera pyralidae; effects aza; achroia grisella ... See more keywords
Small Molecule Inhibitor C188-9 Synergistically Enhances the Demethylated Activity of Low-Dose 5-Aza-2′-Deoxycytidine Against Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2020.00612
Abstract: Aberrant DNA methylation, especially hypermethylation of tumor suppressor genes, has been associated with many cancers' progression. 5-Aza-2′-deoxycytidine (DAC) can reverse hypermethylation-induced gene silencing via regulating DNA methyltransferases (DNMTs) activity, In addition, low-dose of DAC was… read more here.
Keywords: low dose; dac; aza deoxycytidine; pancreatic cancer ... See more keywords
5-Aza-2′-Deoxycytidine Regulates White Adipocyte Browning by Modulating miRNA-133a/Prdm16
Sign Up to like & getrecommendations! Published in 2022 at "Metabolites"
DOI: 10.3390/metabo12111131
Abstract: The conversion of white adipocytes into brown adipocytes improves their thermogenesis and promotes energy consumption. Epigenetic modifications affect related genes and interfere with energy metabolism, and these are the basis of new ideas for obesity… read more here.
Keywords: mirna 133a; aza deoxycytidine; 133a prdm16; white adipocyte ... See more keywords