Enantioselective Synthesis of cis- and trans-Cycloheptyl β-Fluoro Amines by Sequential aza-Henry Addition/Ring-Closing Metathesis.
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DOI: 10.1021/acs.orglett.2c04285
Abstract: The synthesis of 7-membered carbocyclic β-fluoroamines is accomplished by a combination of the enantioselective aza-Henry reaction of aliphatic N-Boc imines and ring-closing metathesis. Use of reductive denitration gives both diastereomers of the β-fluoro amine carbocycle,… read more here.
Keywords: closing metathesis; aza henry; ring closing; synthesis ... See more keywords
Fluorine-induced diastereodivergence discovered in an equally rare enantioselective syn-aza-Henry reaction
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05910f
Abstract: Attention to the aza-Henry reaction, particularly over the past two decades, has resulted in a wide range of effective catalysts for the enantio- and diastereoselective versions, driven by the versatility of the β-amino nitroalkane products… read more here.
Keywords: henry reaction; induced diastereodivergence; aza henry; fluorine induced ... See more keywords