Synthesis of 10-Aza-9-oxakalkitoxin by N-O Bond Formation.
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DOI: 10.1021/acs.orglett.2c00349
Abstract: We describe a formal synthesis of 10-aza-9-oxakalkitoxin, the hydroxalog of the cytotoxic marine natural product kalkitoxin, that features Mukaiyama Markovnikov silyl peroxidation of a terminal alkene and N-O bond formation as the central enabling steps. read more here.
Keywords: aza oxakalkitoxin; synthesis aza; bond formation;