Rapid Access to Hindered α-Amino Acid Derivatives and Benzodiazepin-3-ones from Aza-Oxyallyl Cations.
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DOI: 10.1021/acs.orglett.0c00023
Abstract: Catalyst-free and mild synthetic methods for the construction of hindered α-amino acid derivatives are presented herein. A wide range of hindered amino acid amides can be readily obtained from the reaction of α-halohydroxamates with a… read more here.
Keywords: amino acid; oxyallyl cations; benzodiazepin ones; aza oxyallyl ... See more keywords
Synthesis of Spirofluorenyl-1,2,4-oxadiazinan-5-ones through Metal-Free [3+3] Cycloaddition of N-Vinyl Fluorenone Nitrones with Aza-oxyallyl Cations
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DOI: 10.1055/s-0039-1691490
Abstract: Spirofluorenyl-1,2,4-oxadiazinan-5-ones are prepared in good to excellent yields through metal-free [3+3] cycloaddition of N-vinyl fluorenone nitrones and aza-oxyallyl cations under mild reaction conditions. Detailed studies reveal that N-vinyl fluorenone nitrones show greater reactivity in [3+3]… read more here.
Keywords: spirofluorenyl oxadiazinan; vinyl fluorenone; fluorenone nitrones; fluorenone ... See more keywords