Ru(II)-Catalyzed Oxidative Olefination of Benzamides: Switchable Aza-Michael and Aza-Wacker Reaction for Synthesis of Isoindolinones.
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DOI: 10.1021/acs.orglett.0c01237
Abstract: Selective tandem oxidative C-H olefination-aza-Michael/aza-Wacker reaction of N-arylbenzamides is achieved by fine-tuning between base and additive to access valuable 3-oxoisoindolinyls and 3-oxoisoindolinylidenes, respectively. Careful optimization and control experiments provides a guiding principle in the design… read more here.
Keywords: aza wacker; wacker reaction; oxidative olefination; aza michael ... See more keywords
Palladium-Catalyzed Oxidant Dependent Switchable Aza-Wacker Cyclization and Oxidative Dimerization of Benzimidates.
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DOI: 10.1021/acs.orglett.2c02942
Abstract: An oxidant dependent switchable palladium-catalyzed synthesis of 1,3-oxazines and benzohydrazonates (azines) from O-homoallyl benzimidates has been developed. The reaction involved aza-Wacker-type intramolecular cyclization of O-homoallyl benzimidates with Cu(OAc)2 as oxidant under Pd-catalysis to deliver 4-methylene-1,3-oxazines,… read more here.
Keywords: oxidant dependent; dependent switchable; palladium catalyzed; aza wacker ... See more keywords
Enantioselective Aza-Wacker-Type Cyclization Promoted by Pd-SPRIX Catalyst.
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DOI: 10.1021/acs.orglett.8b02946
Abstract: An enantioselective aza-Wacker-type reaction was developed. When alkenyl sulfonamide substrates were treated with the Pd-SPRIX catalyst in the presence of oxone as an oxidant, the olefin was attacked intramolecularly by the nitrogen nucleophile to construct… read more here.
Keywords: aza wacker; wacker type; enantioselective aza; sprix catalyst ... See more keywords