Design, synthesis and evaluation of azaacridine derivatives as dual-target EGFR and Src kinase inhibitors for antitumor treatment.
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DOI: 10.1016/j.ejmech.2017.05.006
Abstract: Overexpression of EGFR is often associated with advanced stage disease and poor prognosis. In certain cancers, Src works synergistically with EGFR to promote proliferation, survival, invasion and metastasis. Development of dual-target drugs against EGFR and… read more here.
Keywords: dual target; kinase inhibitors; egfr src; target ... See more keywords