Asymmetric synthetic approach to a functionalized azabicyclo[3.3.1]nonane moiety of (+)-sarain A
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DOI: 10.1016/j.tetlet.2017.09.045
Abstract: Abstract This paper describes our efforts toward the asymmetric synthesis of sarain A which led to efficient preparation of a functionalized azabicyclo[3.3.1]nonane moiety. The key to the synthesis relied on a base-catalyzed asymmetric Diels-Alder cycloaddition… read more here.
Keywords: nonane moiety; asymmetric synthetic; azabicyclo nonane; sarain ... See more keywords
The synthesis of 3-azabicyclo[4.3.0]nonane scaffolds from brefeldin A
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DOI: 10.1016/j.tetlet.2020.152006
Abstract: Abstract Brefeldin A (BFA) is a fungal metabolite that displays a wide range of biological activities making it an attractive target for drug discovery. To explore the biological potential of the BFA scaffold an amine-macrocycle… read more here.
Keywords: bfa; azabicyclo nonane; scaffolds brefeldin; synthesis ... See more keywords
New Synthetic Routes to (+)-Uleine and (-)-Tubifolidine: General Approach to 2-Azabicyclo[3.3.1]nonane Indole Alkaloids.
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DOI: 10.1021/acs.orglett.0c00912
Abstract: Novel asymmetric synthetic routes to (+)-uleine and (-)-tubifolidine are reported herein. The regioselective formation of enol triflates from 2-azabicyclo[3.3.1]nonane ketones followed by indolizations of the resultant ene-hydrazides allowed the efficient construction of key indole intermediates,… read more here.
Keywords: routes uleine; tubifolidine general; azabicyclo nonane; synthetic routes ... See more keywords
Design and facile synthesis of spiro-s-tetrazine derivatives of 2,4-diphenyl-3-azabicyclo[3.3.1]nonane-9-one.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220413092052
Abstract: BACKGROUND Literature survey suggested various methods of synthesis of the 3-azabicyclo[3.3.1] nonanes which includes, Mannich reaction, α, α'-Annelation of Cyclic Ketones or through Enamines, Michael addition, Intramolecular Cyclizations etc. However, a mechanism following a Michael… read more here.
Keywords: nonane one; reaction; azabicyclo nonane; synthesis spiro ... See more keywords