Articles with "azd8154 dual" as a keyword



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Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.

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Published in 2021 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c00434

Abstract: Starting from our previously described PI3Kγ inhibitors, we describe the exploration of structure-activity relationships that led to the discovery of highly potent dual PI3Kγδ inhibitors. We explored changes in two positions of the molecules, including… read more here.

Keywords: discovery azd8154; azd8154 dual; discovery; dual pi3k ... See more keywords