Asymmetric Synthesis of Spirofuro[2,3-b]azepine-5,3’-indoline Derivatives via Cycloisomerization/[4+3] Annulation Process under Au/N-Heterocyclic Carbene Relay Catalysis
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00539a
Abstract: A variety of enantioenriched spirofuro[2,3-b]azepine-5,3’-indoline derivatives (dr > 20:1, up to 96% ee) were facilely synthesized through cycloisomerization/asymmetric formal [4+3] cycloaddition reactions of enyne-amides with isatin-derived enals under gold(I)/chiral N-heterocyclic... read more here.
Keywords: spirofuro azepine; cycloisomerization; azepine indoline; indoline derivatives ... See more keywords