Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer letters"
DOI: 10.1016/j.canlet.2022.215613
Abstract: Signal transducer and activator of transcription (Stat)3 is a valid anticancer therapeutic target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory activity of lead compounds to levels previously unseen. The azetidine-based compounds,… read more here.
Keywords: potent azetidine; inhibit stat3; growth; azetidine based ... See more keywords
Stereoselective Access to Azetidine-Based α-Amino Acids and Applications to Small Peptide Synthesis.
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DOI: 10.1021/acs.orglett.0c03131
Abstract: Non-natural azetidine-based amino acids (Aze) present interesting features in protein engineering. A simple organometallic route toward unsaturated carboxylic acid precursors is presented. Subsequent metal-catalyzed asymmetric reduction allowed for the synthesis of a new library of… read more here.
Keywords: amino acids; azetidine based; stereoselective access; small peptide ... See more keywords
Photochemical Strategies Enable the Synthesis of Tunable Azetidine-Based Energetic Materials.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c08191
Abstract: Despite their favorable properties, azetidines are often overlooked as lead compounds across multiple industries. This is often attributed to the challenging synthesis of densely functionalized azetidines in an efficient manner. In this work, we report… read more here.
Keywords: azetidine based; based energetic; synthesis; photochemical strategies ... See more keywords