Discovery of Potent Azetidine-Benzoxazole MerTK Inhibitors with In Vivo Target Engagement.
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DOI: 10.1021/acs.jmedchem.4c01451
Abstract: Inhibition of the receptor tyrosine kinase MerTK by small molecules has the potential to augment the immune response to tumors. Potent, selective inhibitors with high levels of in vivo target engagement are needed to fully… read more here.
Keywords: vivo target; mertk inhibitors; azetidine benzoxazole; target ... See more keywords