Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
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DOI: 10.1021/acsmedchemlett.7b00030
Abstract: Dihydroorotate dehydrogenase (DHODH) is an enzyme necessary for pyrimidine biosynthesis in protozoan parasites of the genus Plasmodium, the causative agents of malaria. We recently reported the identification of novel compounds derived from diversity-oriented synthesis with… read more here.
Keywords: discovery antimalarial; antimalarial azetidine; azetidine carbonitriles; dihydroorotate dehydrogenase ... See more keywords