Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.
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DOI: 10.1021/acs.jmedchem.7b01531
Abstract: Monoacylglycerol lipase (MAGL) is the main enzyme responsible for degradation of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the CNS. MAGL catalyzes the conversion of 2-AG to arachidonic acid (AA), a precursor to the proinflammatory eicosannoids such… read more here.
Keywords: monoacylglycerol lipase; chemistry; piperidine carbamates; magl ... See more keywords