Polycyclic Azetidines and Pyrrolidines via Palladium-Catalyzed Intramolecular Amination of Unactivated C(sp3)-H Bonds.
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DOI: 10.1021/acs.orglett.7b02339
Abstract: A novel strategy to construct complex polycyclic nitrogen-containing heterocycles from aliphatic amines via picolinamide-assisted palladium-catalyzed C-H bond activation reaction was reported. The reaction exhibits broad substrate scope for the synthesis of various azabicyclic scaffolds, including… read more here.
Keywords: via palladium; polycyclic azetidines; palladium catalyzed; pyrrolidines via ... See more keywords