Copper-catalyzed remote C(sp3)–H azidation and oxidative trifluoromethylation of benzohydrazides
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DOI: 10.1038/s41467-019-08741-w
Abstract: The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp3)–H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl radical is thermodynamically favorable and is well-established, the method for the… read more here.
Keywords: trifluoromethylation; remote sp3; azidation oxidative; oxidative trifluoromethylation ... See more keywords