Discovery and Anticancer Activity of Novel 1,3,4-Thiadiazole- and Aziridine-Based Indolin-2-ones via In Silico Design Followed by Supramolecular Green Synthesis
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DOI: 10.1021/acsomega.2c01198
Abstract: Three crucial anticancer scaffolds, namely indolin-2-one, 1,3,4-thiadiazole, and aziridine, are explored to synthesize virtually screened target molecules based on the c-KIT kinase protein. The stem cell factor receptor c-KIT was selected as target because most… read more here.
Keywords: thiadiazole; cell; indolin ones; aziridine ... See more keywords
Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination.
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DOI: 10.1021/jacs.2c07243
Abstract: Natural products containing an aziridine ring, such as mitomycin C and azinomycin B, exhibit antitumor activities by alkylating DNA via their aziridine rings; however, the biosynthetic mechanisms underlying the formation of these rings have not… read more here.
Keywords: via sulfate; aziridine ring; aziridine; formation ... See more keywords
Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine
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DOI: 10.3390/molecules27206869
Abstract: Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid. This method is highly atom economical where… read more here.
Keywords: economical multi; synthesis; atom economical; aziridine ... See more keywords