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   Articles with "aziridine" as a keyword



Recent Developments in the Biosynthesis of Aziridines

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recommendations! Published in 2024 at "ChemBioChem"

DOI: 10.1002/cbic.202400295

Abstract: Only 0.016 % of all known natural products contain an aziridine ring, but this unique structural feature imparts high reactivity and cytotoxicity to the compounds in which it is found. Until 2021, no naturally occurring aziridine‐forming… read more here.

Keywords: recent developments; chemistry; aziridine; developments biosynthesis ... See more keywords

Discovery and Anticancer Activity of Novel 1,3,4-Thiadiazole- and Aziridine-Based Indolin-2-ones via In Silico Design Followed by Supramolecular Green Synthesis

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01198

Abstract: Three crucial anticancer scaffolds, namely indolin-2-one, 1,3,4-thiadiazole, and aziridine, are explored to synthesize virtually screened target molecules based on the c-KIT kinase protein. The stem cell factor receptor c-KIT was selected as target because most… read more here.

Keywords: thiadiazole; cell; indolin ones; aziridine ... See more keywords

Molecular Basis for Enzymatic Aziridine Formation via Sulfate Elimination.

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recommendations! Published in 2022 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.2c07243

Abstract: Natural products containing an aziridine ring, such as mitomycin C and azinomycin B, exhibit antitumor activities by alkylating DNA via their aziridine rings; however, the biosynthetic mechanisms underlying the formation of these rings have not… read more here.

Keywords: via sulfate; aziridine ring; aziridine; formation ... See more keywords

Atom Economical Multi-Substituted Pyrrole Synthesis from Aziridine

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recommendations! Published in 2022 at "Molecules"

DOI: 10.3390/molecules27206869

Abstract: Multi-substituted pyrroles are synthesized from regiospecific aziridine ring-opening and subsequent intramolecular cyclization with a carbonyl group at the γ-position in the presence of Lewis acid or protic acid. This method is highly atom economical where… read more here.

Keywords: economical multi; synthesis; atom economical; aziridine ... See more keywords

A Study on the Biological Activity of Optically Pure Aziridine Phosphines and Phosphine Oxides

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recommendations! Published in 2024 at "Molecules"

DOI: 10.3390/molecules29071430

Abstract: A series of optically pure aziridine phosphines and their corresponding phosphine oxides were synthesized through established chemical methodologies. The compounds were systematically investigated for their biological properties. Notably, all synthesized compounds demonstrated moderate antibacterial activity… read more here.

Keywords: pure aziridine; aziridine; optically pure; phosphine oxides ... See more keywords