Retargeting azithromycin analogues to have dual-modality antimalarial activity
Sign Up to like & getrecommendations! Published in 2020 at "BMC Biology"
DOI: 10.1186/s12915-020-00859-4
Abstract: Background Resistance to front-line antimalarials (artemisinin combination therapies) is spreading, and development of new drug treatment strategies to rapidly kill Plasmodium spp. malaria parasites is urgently needed. Azithromycin is a clinically used macrolide antibiotic proposed… read more here.
Keywords: quick killing; azithromycin analogues; drug; activity ... See more keywords
Targeting malaria parasites with novel derivatives of azithromycin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1063407
Abstract: Introduction The spread of artemisinin resistant Plasmodium falciparum parasites is of global concern and highlights the need to identify new antimalarials for future treatments. Azithromycin, a macrolide antibiotic used clinically against malaria, kills parasites via… read more here.
Keywords: parasites novel; quick killing; targeting malaria; azithromycin analogues ... See more keywords