Enhanced Antitumor Efficacy and Reduced Myelosuppression by a Supramolecular Complex Composed of Azocalix[4]arene and Sunitinib.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c02487
Abstract: Antiangiogenic therapy, which inhibits tumor growth by blocking oxygen and nutrition supply, represents a promising strategy for antineoplastic therapy. However, the widespread biodistribution of antiangiogenic agents often leads to off-target toxicities, including hematotoxicity and myelosuppression.… read more here.
Keywords: myelosuppression; azocalix arene; efficacy; enhanced antitumor ... See more keywords
Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent.
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DOI: 10.1021/acsami.4c13762
Abstract: Many active pharmaceutical ingredients have a specific bitter taste. To enhance patient compliance and treatment efficacy, taste-masking agents are crucial in oral drug formulations. Confronting numerous bitter drug molecules with varied structures, the pharmaceutical field… read more here.
Keywords: azocalix arene; universal effective; masking agent; sulfonated azocalix ... See more keywords
High-affinity 1 : 2 recognition based on naphthyl-azocalix[4]arene and its application as a cleavable noncovalent connector in constructing responsive supramolecular polymeric materials
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DOI: 10.1039/d5sc00075k
Abstract: Macrocyclic hosts which can bind two guests simultaneously with high affinity, such as cucurbit[8]uril, are highly useful for a wide range of applications by acting as noncovalent connectors. However, the integration of stimuli-controlled release properties… read more here.
Keywords: high affinity; noncovalent connector; azocalix arene; cleavable noncovalent ... See more keywords