Diastereoselective synthesis of tetrahydrobenzo[b]azocines by Lu(OTf)3-catalyzed [4+4] cycloaddition of donor-acceptor cyclobutanes with anthranils.
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DOI: 10.1039/d2cc00829g
Abstract: The construction of N-heterocyclic eight-membered rings remains challenging due to unfavorable transannular strain. Herein, we report a Lu(OTf)3-catalyzed formal [4+4] cycloaddition reaction of cyclobutane 1,1-diesters with anthranils to deliver oxa-bridged eight-membered heterocycles. This methodology provides… read more here.
Keywords: diastereoselective synthesis; otf catalyzed; tetrahydrobenzo azocines; azocines otf ... See more keywords