A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors.
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron letters"
DOI: 10.1016/j.tetlet.2017.09.070
Abstract: The study and development of azole-based CYP51 inhibitors is an active area of research across disciplines of biochemistry, pharmacology and infectious disease. Support of in vitro and in vivo studies require the development of robust… read more here.
Keywords: convergent scalable; scalable stereoselective; cyp51 inhibitors; azole ... See more keywords
Azole-Induced Color Vision Deficiency Associated with Thyroid Hormone Signaling: An Integrated In Vivo, In Vitro, and In Silico Study.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.2c05328
Abstract: Azoles that are used in pesticides, pharmaceuticals, and personal care products can have toxic effects on fish. However, there is no information regarding azole-induced visual disorder associated with thyroid disruption. We evaluated changes in retinal… read more here.
Keywords: azole; color; azole induced; thyroid hormone ... See more keywords
Detection of azole-susceptible and azole-resistant Aspergillus coinfection by cyp51A PCR amplicon melting curve analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx262
Abstract: Background The AsperGenius® assay is a multiplex real-time PCR test that allows the simultaneous detection of Aspergillus species and identification of the most common mutations in the Aspergillus fumigatus cyp51A gene conferring resistance (TR34/L98H and… read more here.
Keywords: detection; melting curve; azole; azole resistant ... See more keywords
High detection rate of azole-resistant Aspergillus fumigatus after treatment with azole antifungal drugs among patients with chronic pulmonary aspergillosis in a single hospital setting with low azole resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Medical mycology"
DOI: 10.1093/mmy/myaa052
Abstract: The prevalence of azole-resistant Aspergillus fumigatus (ARAF) among chronic pulmonary aspergillosis (CPA) patients treated with azoles in Japan is unknown. The aim of this study was to determine the detection rate of ARAF in isolates… read more here.
Keywords: azole; resistance; detection rate; cpa patients ... See more keywords
Azole-resistant and -susceptible Aspergillus fumigatus isolates show comparable fitness and azole treatment outcome in immunocompetent mice
Sign Up to like & getrecommendations! Published in 2018 at "Medical Mycology"
DOI: 10.1093/mmy/myx109
Abstract: No data are available on the in vivo impact of infections with in vitro azole-resistant Aspergillus fumigatus in immunocompetent hosts. Here, the aim was to investigate fungal fitness and treatment response in immunocompetent mice infected… read more here.
Keywords: aspergillus fumigatus; treatment; azole; azole resistant ... See more keywords
Determining Susceptibility in Candida Vaginal Isolates
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02366-21
Abstract: Antifungal drug susceptibility tests (AST) for Candida albicans are increasingly demanded for women with refractory or recurrent Candida vaginitis due to fluconazole resistance. Given reduced activity of azole drugs at pH levels found in women… read more here.
Keywords: azole; candida vaginitis; vaginal isolates; susceptibility ... See more keywords
A Novel Environmental Azole Resistance Mutation in Aspergillus fumigatus and a Possible Role of Sexual Reproduction in Its Emergence
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DOI: 10.1128/mbio.00791-17
Abstract: ABSTRACT This study investigated the dynamics of Aspergillus fumigatus azole-resistant phenotypes in two compost heaps with contrasting azole exposures: azole free and azole exposed. After heat shock, to which sexual but not asexual spores are… read more here.
Keywords: resistance mutation; compost; azole; resistance ... See more keywords
Current Status of Azole-resistant Aspergillus fumigatus Isolates in East Asia.
Sign Up to like & getrecommendations! Published in 2018 at "Medical mycology journal"
DOI: 10.3314/mmj.18.010
Abstract: Aspergillus fumigatus is a saprophytic fungus that is a major causative pathogen for aspergillosis. Only a few classes of antifungals are used for treating this life-threatening fungal infection. Azoles are the first-line drugs and are… read more here.
Keywords: fumigatus isolates; aspergillus fumigatus; azole; azole resistant ... See more keywords
4-Allyl-2-methoxyphenol modulates the expression of genes involved in efflux pump, biofilm formation and sterol biosynthesis in azole resistant Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1103957
Abstract: Introduction Antifungal therapy for aspergillosis is becoming problematic because of the toxicity of currently available drugs, biofilm formation on host surface, and increasing prevalence of azole resistance in Aspergillus fumigatus. Plants are rich source of… read more here.
Keywords: fumigatus; azole; biofilm formation; azole resistant ... See more keywords