Versatile Diazomethane Sulfonamide for Expedited Exploration of Azole‐Based Carbonic Anhydrase Inhibitors via [3+2] Cycloaddition
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DOI: 10.1002/cmdc.202200607
Abstract: A newly introduced diazo reagent, 1‐diazo‐N,N‐bis(4‐methoxybenzyl)methanesulfonamide, enables access to a range of azole‐based primary sulfonamides via [3+2] cycloaddition followed by protecting group removal. Such compounds are representative of the sulfonamide chemical space highly relevant but… read more here.
Keywords: azole based; via cycloaddition; carbonic anhydrase;
Azole Based Acetohydrazide Derivatives of Cinnamaldehyde Target and Kill Candida albicans by Causing Cellular Apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00030
Abstract: Opportunistic fungal pathogens including Candida albicans are responsible for the alarming rise in hospital acquired infections and millions of deaths worldwide. The current treatment modalities are not enough to handle this situation, and therefore, new… read more here.
Keywords: acetohydrazide derivatives; cinnamaldehyde target; candida albicans; azole based ... See more keywords
Azole-Based Antibacterial Agents: A Review on Multistep Synthesis Strategies and Biology
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DOI: 10.1080/10406638.2021.1938615
Abstract: This article reviews current multistep synthesis strategies of azole-based antibacterial agents. In recent years, extensive use of chemical agents in treating different diseases resulted in the dev... read more here.
Keywords: antibacterial agents; synthesis strategies; biology; based antibacterial ... See more keywords
Framework disorder and its effect on selective hysteretic sorption of a T-shaped azole-based metal–organic framework
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DOI: 10.1107/s2052252518015749
Abstract: The effect of framework (pore) disorder on gas sorption of azole-based isoreticular Cu(II) MOFs with rtl (rutile) topology and characteristic 1D tubular pore channels is investigated for the first time. read more here.
Keywords: sorption; framework disorder; azole based; effect ... See more keywords