Synergistic effects of tea polyphenol epigallocatechin 3-O-gallate and azole drugs against oral Candida isolates.
Sign Up to like & getrecommendations! Published in 2019 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2019.01.011
Abstract: BACKGROUND The antifungal drug resistance has become an emerging problem in the management of candida infections worldwide. The objective of this study was to examine the efficacy of epigallocatechin 3-O-gallate (EGCG) alone and in combination… read more here.
Keywords: oral candida; candida isolates; azole drugs; microscopy ... See more keywords
Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-37330-y
Abstract: Flavocytochrome P450 BM3 is a natural fusion protein constructed of cytochrome P450 and NADPH-cytochrome P450 reductase domains. P450 BM3 binds and oxidizes several mid- to long-chain fatty acids, typically hydroxylating these lipids at the ω-1,… read more here.
Keywords: p450 bm3; azole drugs; bm3; insights p450 ... See more keywords
Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs
Sign Up to like & getrecommendations! Published in 2020 at "Virulence"
DOI: 10.1080/21505594.2020.1838741
Abstract: ABSTRACT With the rapid increase in the frequency of azole-resistant species, combination therapy appears to be a promising tool to augment the antifungal activity of azole drugs against resistant Candida species. Here, we report the… read more here.
Keywords: azole drugs; candida; candida auris; antiemetic agent ... See more keywords
The changing spectrum of Saccharomycotina yeasts causing candidemia: phylogeny mirrors antifungal susceptibility patterns for azole drugs and amphothericin B.
Sign Up to like & getrecommendations! Published in 2019 at "FEMS yeast research"
DOI: 10.1093/femsyr/foz037
Abstract: Ascomycetous yeast species belonging to the subphylum Saccharomycotina (Ascomycota, Fungi) may cause a variety of pathologies in humans. Candida albicans accounts for almost half of candidemia cases but the emergence of uncommon yeasts in the… read more here.
Keywords: susceptibility patterns; yeasts causing; azole drugs; susceptibility ... See more keywords
Heterologous Expression of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provides Tools for Antifungal Discovery
Sign Up to like & getrecommendations! Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01131-18
Abstract: Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are modest for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has… read more here.
Keywords: azole drugs; full length; fungal pathogens; discovery ... See more keywords
Synergic Effect of Phthalide Lactones and Fluconazole and Its New Analogues as a Factor Limiting the Use of Azole Drugs against Candidiasis
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11111500
Abstract: The resistance of Candida albicans and other pathogenic yeasts to azole antifungal drugs has increased rapidly in recent years and is a significant problem in clinical therapy. The current state of pharmacological knowledge precludes the… read more here.
Keywords: azole drugs; limiting use; effect; albicans atcc ... See more keywords