The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda
Sign Up to like & getrecommendations! Published in 2020 at "Fungal Biology Reviews"
DOI: 10.1016/j.fbr.2020.10.003
Abstract: Abstract Azole resistance is a concern for the management of diseases caused by Aspergillus fumigatus in humans. Azole fungicide use in the environment has been identified as a possible cause for development of resistance, which… read more here.
Keywords: research; resistance; azole resistance; health ... See more keywords
Azole-resistant Aspergillus fumigatus in the Italian environment.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2018.10.017
Abstract: OBJECTIVES Azole resistance in Aspergillus fumigatus environmental and clinical isolates is recognised as an emerging problem worldwide. Development of azole resistance may be environmentally driven because of the massive use of azole fungicides in agriculture.… read more here.
Keywords: aspergillus fumigatus; azole resistant; resistance; azole resistance ... See more keywords
Exploring the molecular mechanism of azole resistance in Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2019 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2019.100915
Abstract: Aspergillus infections are increasingly recognized as a global health problem because of limited antifungal drugs and occurrence of azole resistance worldwide. More cyp51-mediated and non-cyp51-mediated mechanisms of azole resistance have been identified in clinical and… read more here.
Keywords: fumigatus; exploring molecular; resistance; mechanism azole ... See more keywords
Calcium signaling pathway is involved in non-CYP51 azole resistance in Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2019 at "Medical mycology"
DOI: 10.1093/mmy/myy075
Abstract: The opportunistic fungal pathogen Aspergillus fumigatus, which is one of the primary airborne ascomycete pathogens and allergens worldwide, causes invasive fungal infections, which have high morbidity and mortality rates among immunosuppressed patients. The abuse of… read more here.
Keywords: aspergillus fumigatus; drug; signaling pathway; resistance ... See more keywords
Azole resistance among clinical isolates of Aspergillus fumigatus in Lima-Peru.
Sign Up to like & getrecommendations! Published in 2019 at "Medical mycology"
DOI: 10.1093/mmy/myz032
Abstract: Azole resistance among Aspergillus fumigatus isolates, which is mainly related to mutations in the cyp51A gene, is a concern because it is rising, worldwide disseminated, and associated with treatment failure and death. Data on azole… read more here.
Keywords: aspergillus fumigatus; mycology; resistance among; resistance ... See more keywords
An expanded Agar-Based Screening method for azole resistant Aspergillus fumigatus.
Sign Up to like & getrecommendations! Published in 2021 at "Mycoses"
DOI: 10.1111/myc.13400
Abstract: Antifungal susceptibility testing is an essential tool for guiding antifungal therapy. Reference methods are complex and usually only available in specialized laboratories. We have designed an expanded agar-based screening method for the detection of azole… read more here.
Keywords: fumigatus; agar based; azole resistant; azole resistance ... See more keywords
Collateral consequences of agricultural fungicides on pathogenic yeasts: a One Health perspective to tackle azole resistance.
Sign Up to like & getrecommendations! Published in 2021 at "Mycoses"
DOI: 10.1111/myc.13404
Abstract: Candida and Cryptococcus affect millions of people yearly, being responsible for a wide array of clinical presentations, including life-threatening diseases. Interestingly, most human-pathogenic yeasts are not restricted to the clinical setting, as they are also… read more here.
Keywords: resistance; azole resistance; one health; pathogenic yeasts ... See more keywords
Azole resistance in Aspergillus fumigatus. The first 2‐year's Data from the Danish National Surveillance Study, 2018–2020
Sign Up to like & getrecommendations! Published in 2022 at "Mycoses"
DOI: 10.1111/myc.13426
Abstract: Azole resistance complicates treatment of patients with invasive aspergillosis with an increased mortality. Azole resistance in Aspergillus fumigatus is a growing problem and associated with human and environmental azole use. Denmark has a considerable and… read more here.
Keywords: aspergillus fumigatus; resistance aspergillus; resistance; azole resistance ... See more keywords
Gradient diffusion strips for detecting azole resistance in Aspergillus fumigatus sensu lato
Sign Up to like & getrecommendations! Published in 2022 at "Mycoses"
DOI: 10.1111/myc.13541
Abstract: Studies comparing gradient diffusion strips (GDSs) and the EUCAST E.Def 9.4 microdilution method are scarce, thwarted by a low number of isolates, and restricted to selected antifungal agents. read more here.
Keywords: gradient diffusion; azole resistance; strips detecting; diffusion strips ... See more keywords
Deletion of cox7c Results in Pan-Azole Resistance in Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00151-22
Abstract: In Aspergillus fumigatus, the most prevalent resistance to azoles results from mutational modifications of the azole target protein Cyp51A, but there are non-cyp51A mutants resistant to azoles, and the mechanisms underlying the resistance of these… read more here.
Keywords: deletion; aspergillus fumigatus; resistance; azole resistance ... See more keywords
Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus
Sign Up to like & getrecommendations! Published in 2017 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01083-17
Abstract: ABSTRACT The global emergence of azole-resistant Aspergillus fumigatus strains is a growing public health concern. Different patterns of azole resistance are linked to mutations in cyp51A. Therefore, accurate characterization of the mechanisms underlying azole resistance… read more here.
Keywords: fumigatus; aspergillus fumigatus; azole resistant; resistance ... See more keywords