N-Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist's Toolbox.
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DOI: 10.1021/acs.jmedchem.0c01457
Abstract: Introducing trifluoromethyl groups is a common strategy to improve the properties of biologically active compounds. However, N-trifluoromethyl moieties on amines and azoles are very rarely used. To evaluate their suitability in drug design, we synthesized… read more here.
Keywords: amines azoles; chemistry; trifluoromethyl azoles; trifluoromethyl ... See more keywords