Dose selection for aztreonam-avibactam, including adjustments for renal impairment, for Phase IIa and Phase III evaluation
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DOI: 10.1007/s00228-023-03609-x
Abstract: A series of iterative population pharmacokinetic (PK) modeling and probability of target attainment (PTA) analyses based on emerging data supported dose selection for aztreonam-avibactam, an investigational combination antibiotic for serious Gram-negative bacterial infections. Two iterations… read more here.
Keywords: aztreonam avibactam; dose selection; selection aztreonam; renal impairment ... See more keywords
In vitro activity of aztreonam-avibactam (ATM-AVI) against a global collection of Klebsiella pneumoniae, collected from defined culture sources, in 2016 and 2017.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.08.004
Abstract: OBJECTIVES This study reports on the activity of aztreonam-avibactam against a collection of Klebsiella pneumoniae collected in 2016 and 2017. METHODS Non-duplicate isolates of K. pneumoniae were collected from four regions (Africa/Middle East, n=785; Asia-Pacific,… read more here.
Keywords: culture sources; aztreonam avibactam; pneumoniae collected; activity ... See more keywords
Past, present, and future perspectives on aztreonam and avibactam
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DOI: 10.1080/14787210.2025.2473047
Abstract: ABSTRACT Introduction Aztreonam is a monobactam antibiotic approved in 1986 to treat infections caused by aerobic Gram-negative bacteria, but, together with cephalosporins, lost clinical utility due to the emergence of extended-spectrum β-lactamases (ESBLs) and novel… read more here.
Keywords: aztreonam avibactam; avibactam; gram negative; present future ... See more keywords
Aztreonam/avibactam activity against Enterobacterales from European medical centres: summary of 5 years of surveillance prior to approval for clinical use (2019–2023)
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkaf161
Abstract: Abstract Objectives To evaluate the in vitro activity of aztreonam/avibactam against Enterobacterales from European medical centres during the 5-year period prior to its approval for clinical use in Europe. Methods Thirty thousand seventy-four Enterobacterales isolates… read more here.
Keywords: aztreonam avibactam; enterobacterales european; medical centres; approval ... See more keywords
Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz497
Abstract: Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study… read more here.
Keywords: safety; aztreonam avibactam; min; pharmacokinetics safety ... See more keywords
P-1083. Antimicrobial Activity of Aztreonam-Avibactam and Comparator Agents against a Large Collection of Stenotrophomonas maltophilia Isolates Collected in United States Medical Centers (2019-2023)
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DOI: 10.1093/ofid/ofae631.1271
Abstract: Abstract Background The occurrence of S. maltophilia infections has increased continuously in the last few years. We evaluated the in vitro activities of aztreonam-avibactam (ATM-AVI) and comparators against a large collection of S. maltophilia clinical… read more here.
Keywords: aztreonam avibactam; activity aztreonam; atm avi; large collection ... See more keywords
P-1508. In Vitro Activity of Aztreonam-avibactam against Enterobacterales Isolates Producing Multiple β-lactamases Collected Globally as a Part of the ATLAS Global Surveillance Program from 2018-2022
Sign Up to like & getrecommendations! Published in 2025 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofae631.1677
Abstract: Abstract Background Aztreonam-avibactam (ATM-AVI) is a β-lactam/β-lactamase inhibitor combination to treat infections caused by Gram-negative organisms, particularly those carrying metallo-β-lactamases (MBLs) and other β-lactamases. Aztreonam is stable to hydrolysis by MBLs and avibactam inhibits Class… read more here.
Keywords: aztreonam avibactam; enterobacterales isolates; part atlas; atm avi ... See more keywords
Aztreonam-avibactam Demonstrates Potent Activity Against Carbapenem-resistant Enterobacterales Collected From US Medical Centers Over a 6-year Period (2017–2022)
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DOI: 10.1093/ofid/ofaf250
Abstract: Abstract Background Carbapenem-resistant Enterobacterales (CREs) are a major public health threat because treatment options are limited. The predominant resistance mechanism in CREs is the production of carbapenemases. Aztreonam-avibactam was shown to possess activity against CREs… read more here.
Keywords: aztreonam avibactam; avibactam; resistant enterobacterales; carbapenem resistant ... See more keywords
Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing Enterobacterales in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00486-21
Abstract: Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory… read more here.
Keywords: producing enterobacterales; metallo beta; aztreonam avibactam; resistance laboratory ... See more keywords
In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015
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DOI: 10.1128/aac.00592-18
Abstract: Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in… read more here.
Keywords: ceftazidime avibactam; methodology; aztreonam avibactam; resistance ... See more keywords
Activity of aztreonam-avibactam, cefiderocol, and cefepime-taniborbactam against a global collection of genetically characterized metallo-β-lactamase-producing Enterobacterales
Sign Up to like & getrecommendations! Published in 2025 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00842-25
Abstract: ABSTRACT We evaluated the activity of aztreonam-avibactam and comparators tested against 490 MBL-producing Enterobacterales isolates collected in 27 countries during 2019–2022. The most common MBL was NDM-1, which was detected among 307 isolates. The genes… read more here.
Keywords: mbl producing; aztreonam avibactam; activity aztreonam; cefepime taniborbactam ... See more keywords