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Published in 2020 at "Journal of global antimicrobial resistance"
DOI: 10.1016/j.jgar.2020.08.004
Abstract: OBJECTIVES This study reports on the activity of aztreonam-avibactam against a collection of Klebsiella pneumoniae collected in 2016 and 2017. METHODS Non-duplicate isolates of K. pneumoniae were collected from four regions (Africa/Middle East, n=785; Asia-Pacific,…
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Keywords:
culture sources;
aztreonam avibactam;
pneumoniae collected;
activity ... See more keywords
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Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkz497
Abstract: Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study…
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Keywords:
safety;
aztreonam avibactam;
min;
pharmacokinetics safety ... See more keywords
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Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00486-21
Abstract: Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory…
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Keywords:
producing enterobacterales;
metallo beta;
aztreonam avibactam;
resistance laboratory ... See more keywords
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Published in 2018 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00592-18
Abstract: Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in…
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Keywords:
ceftazidime avibactam;
methodology;
aztreonam avibactam;
resistance ... See more keywords
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Published in 2022 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01390-22
Abstract: The increasing bacterial antibiotic resistance is a serious threat to global public health, which demands novel antimicrobial medicines and treatment strategies. Eravacycline is a newly approved antibiotic that belongs to the tetracycline antibiotics. ABSTRACT The…
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Keywords:
aztreonam avibactam;
development;
combination;
resistance eravacycline ... See more keywords
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2
Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.04873-22
Abstract: Infections caused by multidrug-resistant (MDR) Enterobacterales, especially carbapenem-resistant Enterobacterales (CRE), have been a challenging clinical problem due to the limited therapeutic options. Therefore, the need to develop novel antimicrobial agents and evaluate their activities against…
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Keywords:
avibactam eravacycline;
aztreonam avibactam;
cefoselis;
enterobacterales isolates ... See more keywords
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Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.926209
Abstract: Aztreonam/avibactam (AZA), as one of the novel β-lactamases and β-lactamase inhibitor combinations, is considered to be a promising option for bloodstream infection (BSI) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp). However, decreased susceptibility of AZA activity in…
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Keywords:
decreased susceptibility;
aztreonam avibactam;
bloodstream infection;
susceptibility ... See more keywords
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Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1047109
Abstract: Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be elucidated. We performed a study to investigate the…
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Keywords:
aztreonam avibactam;
escherichia coli;
pbp3;
avibactam ... See more keywords
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Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.771910
Abstract: Objectives: This work was to investigate the activity and optimal treatments of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections caused by carbapenem resistant Klebsiella pneumoniae (BSIs-CRKP). Methods: A total of 318 nonduplicate BSIs-CRKP isolates…
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Keywords:
aztreonam avibactam;
avibactam;
ceftazidime avibactam;
infusion ... See more keywords