Articles with "aztreonam avibactam" as a keyword



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In vitro activity of aztreonam-avibactam (ATM-AVI) against a global collection of Klebsiella pneumoniae, collected from defined culture sources, in 2016 and 2017.

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Published in 2020 at "Journal of global antimicrobial resistance"

DOI: 10.1016/j.jgar.2020.08.004

Abstract: OBJECTIVES This study reports on the activity of aztreonam-avibactam against a collection of Klebsiella pneumoniae collected in 2016 and 2017. METHODS Non-duplicate isolates of K. pneumoniae were collected from four regions (Africa/Middle East, n=785; Asia-Pacific,… read more here.

Keywords: culture sources; aztreonam avibactam; pneumoniae collected; activity ... See more keywords
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Pharmacokinetics and safety of aztreonam/avibactam for the treatment of complicated intra-abdominal infections in hospitalized adults: results from the REJUVENATE study

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Published in 2019 at "Journal of Antimicrobial Chemotherapy"

DOI: 10.1093/jac/dkz497

Abstract: Abstract Objectives To investigate pharmacokinetics (PK) and safety (primary objectives) and efficacy (secondary objective) of the investigational monobactam/β-lactamase inhibitor combination aztreonam/avibactam in patients with complicated intra-abdominal infection (cIAI). Methods This Phase 2a open-label, multicentre study… read more here.

Keywords: safety; aztreonam avibactam; min; pharmacokinetics safety ... See more keywords
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Aztreonam-Avibactam Susceptibility Testing Program for Metallo-Beta-Lactamase-Producing Enterobacterales in the Antibiotic Resistance Laboratory Network, March 2019 to December 2020

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Published in 2021 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00486-21

Abstract: Aztreonam-avibactam is a drug combination pending phase 3 clinical trials and is suggested for treatment of severe infections caused by metallo-beta-lactamase (MBL)-producing Enterobacterales by combining ceftazidime-avibactam and aztreonam. Beginning in 2019, four Antibiotic Resistance Laboratory… read more here.

Keywords: producing enterobacterales; metallo beta; aztreonam avibactam; resistance laboratory ... See more keywords
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In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015

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Published in 2018 at "Antimicrobial Agents and Chemotherapy"

DOI: 10.1128/aac.00592-18

Abstract: Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in… read more here.

Keywords: ceftazidime avibactam; methodology; aztreonam avibactam; resistance ... See more keywords
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Development of Resistance to Eravacycline by Klebsiella pneumoniae and Collateral Sensitivity-Guided Design of Combination Therapies

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Published in 2022 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01390-22

Abstract: The increasing bacterial antibiotic resistance is a serious threat to global public health, which demands novel antimicrobial medicines and treatment strategies. Eravacycline is a newly approved antibiotic that belongs to the tetracycline antibiotics. ABSTRACT The… read more here.

Keywords: aztreonam avibactam; development; combination; resistance eravacycline ... See more keywords

In Vitro Activities of Aztreonam-Avibactam, Eravacycline, Cefoselis, and Other Comparators against Clinical Enterobacterales Isolates: a Multicenter Study in China, 2019

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Published in 2023 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.04873-22

Abstract: Infections caused by multidrug-resistant (MDR) Enterobacterales, especially carbapenem-resistant Enterobacterales (CRE), have been a challenging clinical problem due to the limited therapeutic options. Therefore, the need to develop novel antimicrobial agents and evaluate their activities against… read more here.

Keywords: avibactam eravacycline; aztreonam avibactam; cefoselis; enterobacterales isolates ... See more keywords
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Epidemiology and Genomic Characteristics of Bloodstream Infection Caused by Carbapenem-Resistant Klebsiella pneumoniae With Decreased Susceptibility to Aztreonam/Avibactam in China

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Published in 2022 at "Frontiers in Cellular and Infection Microbiology"

DOI: 10.3389/fcimb.2022.926209

Abstract: Aztreonam/avibactam (AZA), as one of the novel β-lactamases and β-lactamase inhibitor combinations, is considered to be a promising option for bloodstream infection (BSI) of carbapenem-resistant Klebsiella pneumoniae (CR-Kp). However, decreased susceptibility of AZA activity in… read more here.

Keywords: decreased susceptibility; aztreonam avibactam; bloodstream infection; susceptibility ... See more keywords
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Resistance to aztreonam-avibactam due to CTX-M-15 in the presence of penicillin-binding protein 3 with extra amino acids in Escherichia coli

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Published in 2022 at "Frontiers in Microbiology"

DOI: 10.3389/fmicb.2022.1047109

Abstract: Aztreonam-avibactam is a promising combination to treat carbapenem-resistant Enterobacterales including coverage for metallo-β-lactamases. Escherichia coli strains resistant to aztreonam-avibactam have emerged but resistance mechanisms remain to be elucidated. We performed a study to investigate the… read more here.

Keywords: aztreonam avibactam; escherichia coli; pbp3; avibactam ... See more keywords
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Antibacterial Activity and Optimal Treatment of Ceftazidime-Avibactam and Aztreonam-Avibactam Against Bloodstream Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae

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Published in 2021 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2021.771910

Abstract: Objectives: This work was to investigate the activity and optimal treatments of ceftazidime-avibactam (CZA) and aztreonam-avibactam (AZA) against bloodstream infections caused by carbapenem resistant Klebsiella pneumoniae (BSIs-CRKP). Methods: A total of 318 nonduplicate BSIs-CRKP isolates… read more here.

Keywords: aztreonam avibactam; avibactam; ceftazidime avibactam; infusion ... See more keywords