Repurposing Nimesulide, a Potent Inhibitor of the B0AT1 Subunit of the SARS-CoV-2 Receptor, as a Therapeutic Adjuvant of COVID-19
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DOI: 10.1177/2472555220934421
Abstract: The global pandemic caused by the SARS-CoV-2 infection is a health emergency that needs to be addressed immediately. The international scientific community, following World Health Organization (WHO) indications, launched different trials for testing drugs putatively… read more here.
Keywords: nimesulide potent; b0at1; covid; repurposing nimesulide ... See more keywords
Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases
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DOI: 10.3389/fphar.2020.00140
Abstract: Lack of B0AT1 (SLC6A19) partially protects mice against the onset of non-alcoholic steatohepatitis (NASH). To achieve a similar outcome through pharmacological treatment, we improved previously identified inhibitors of B0AT1 by medicinal chemistry and identified second… read more here.
Keywords: b0at1; amino acid; b0at1 slc6a19; novel chemical ... See more keywords