Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27103
Abstract: High nuclear expression of G protein‐coupled receptors, including kinin B1 receptors (B1R), has been observed in several human cancers, but the clinical significance of this is unknown. We put forward the hypothesis that these “nuclearized”… read more here.
Keywords: breast cancer; cell penetrant; b1r; cell ... See more keywords
Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0552-4
Abstract: Hemorrhagic transformation (HT) is a major complication of ischemic stroke and further deteriorates neurological outcomes. Bradykinin 1 receptor (B1R) has been proven to mediate vasculo-toxicity in various experimental models. However, its role in the development… read more here.
Keywords: ischemic stroke; bradykinin receptor; type; b1r ... See more keywords
STrategically Acquired Gradient Echo (STAGE) imaging, part II: Correcting for RF inhomogeneities in estimating T1 and proton density.
Sign Up to like & getrecommendations! Published in 2018 at "Magnetic resonance imaging"
DOI: 10.1016/j.mri.2017.10.006
Abstract: PURPOSE To develop a method for mapping the B1 transmit (B1t) and B1 receive (B1r) fields from two gradient echo datasets each with a different flip angle and from these two images obtain accurate T1… read more here.
Keywords: echo stage; acquired gradient; gradient echo; strategically acquired ... See more keywords
Bradykinin B1 receptor antagonist protects against cold stress–induced erectile dysfunction in rats
Sign Up to like & getrecommendations! Published in 2023 at "Sexual Medicine"
DOI: 10.1093/sexmed/qfac004
Abstract: Abstract Background Erectile dysfunction (ED) demonstrates seasonal variation with higher rates in winter, and we hypothesize that endothelial damage in erectile tissue caused by bradykinin receptor B1 (B1R) might be detrimental to this change. Aim… read more here.
Keywords: stress; cold stress; b1r; endothelial damage ... See more keywords
Kininase I inhibition reduces B1R mediated signaling and attenuates angiotensin II-induced hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5730340
Abstract: Objectives: Kininase I, or carboxypeptidase M and N (CPM/CPN), metabolizes bradykinin and kallidin into endogenous kinin B1 receptor (B1R) agonists. B1R expression in the brain is linked to neuroinflammation and autonomic dysfunction, and the development… read more here.
Keywords: kininase; hypertension; b1r; cpnko mice ... See more keywords
Kinin B1 receptor antagonism prevents the transactivation of brain TLR4 in angiotensin II-induced hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731411
Abstract: Background and Hypothesis: Toll like receptor 4 (TLR4) is a component of the innate immune system and is associated with hypertension due to its role in inflammation and oxidative stress. TLR4 inhibition in the brain… read more here.
Keywords: b1r; physiology; induced hypertension; tlr4 ... See more keywords
Kinin B1 Receptor Mediates Renal Injury and Remodeling in Hypertension
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.780834
Abstract: Despite many readily available therapies, hypertensive kidney disease remains the second most prevalent cause of end-stage renal disease after diabetes, and continues to burden patient populations and escalate morbidity and mortality rates. Kinin B1 receptor… read more here.
Keywords: renal injury; b1r; kidney; hypertension ... See more keywords
Kinin B1 Receptor Mediates Bidirectional Interaction between Neuroinflammation and Oxidative Stress
Sign Up to like & getrecommendations! Published in 2023 at "Antioxidants"
DOI: 10.3390/antiox12010150
Abstract: Hypertension is associated with increased expression of kinin B1 receptors (B1R) and increased levels of pro-inflammatory cytokines within the neurons. We previously reported that angiotensin II (Ang II) upregulates B1R expression and can induce neuroinflammation… read more here.
Keywords: stress; b1r; oxidative stress; neuroinflammation oxidative ... See more keywords
Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22010145
Abstract: Angiotensin converting enzyme 2 (ACE2) is a critical component of the compensatory axis of the renin angiotensin system. Alterations in ACE2 gene and protein expression, and activity mediated by A Disintegrin And Metalloprotease 17 (ADAM17),… read more here.
Keywords: kinin; ace2 shedding; shedding neurons; activation ... See more keywords
Kinin B2 and B1 Receptors Activation Sensitize the TRPA1 Channel Contributing to Anastrozole-Induced Pain Symptoms
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15041136
Abstract: Aromatase inhibitors (AIs) cause symptoms of musculoskeletal pain, and some mechanisms have been proposed to explain them. However, signaling pathways downstream from kinin B2 (B2R) and B1 (B1R) receptor activation and their possible sensitizing of… read more here.
Keywords: b1r; trpa1 channel; pain; anastrozole induced ... See more keywords