CRISPR/Cas9 Ribonucleoprotein Complex-Mediated Efficient B2M Knockout in Human Induced Pluripotent Stem Cells (iPSCs).
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/7651_2021_352
Abstract: Advances in induced pluripotent stem cell (iPSC) technology provide a renewable source of cells for tissue regeneration and therefore hold great promise for cell replacement therapy. However, immune rejection of allograft due to human leukocyte… read more here.
Keywords: b2m; pluripotent stem; induced pluripotent; stem ... See more keywords
Assessment of internal controls for data normalization of gene expression after different bacterial stimulation by quantitative real-time PCR in golden pompano Trachinotus blochii
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Oceanology and Limnology"
DOI: 10.1007/s00343-019-9053-5
Abstract: Trachinotus blochii is one of the important commercial fish species. In this study, we aim to confirm the reliability reference genes in T. blochii during different bacterial challenge through quantitative real-time PCR (qRT-PCR). The expression… read more here.
Keywords: 18s rrna; rrna b2m; b2m; spleen kidney ... See more keywords
Association of beta-2-microglobulin and cardiovascular events and mortality: A systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2021 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2021.01.018
Abstract: Background and aims Beta-2-microglobulin (B2M) has been suggested as an emerging biomarker for cardiovascular diseases (CVD), including coronary heart disease (CHD) and stroke, and mortality. Methods Three databases were searched from inception to January 2,… read more here.
Keywords: b2m; beta microglobulin; mortality; cvd ... See more keywords
B2M overexpression correlates with malignancy and immune signatures in human gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-84465-6
Abstract: Because of the limited treatment strategy of gliomas, the key of diagnosis and treatment is finding new molecular biomarkers. Here, we explored the potential of β2-microglobulin (B2M) to serve as a hopeful candidate for immunotherapy… read more here.
Keywords: gliomas; overexpression correlates; b2m; b2m expression ... See more keywords
‘Evaluation of beta-2-microglobulin and neuron-specific enolase as prognostic factors in patients over 65 years of age with frailty syndrome hospitalized for acute coronary syndrome’
Sign Up to like & getrecommendations! Published in 2024 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001343
Abstract: Background The aim of the study is to assess the value of beta-2-microglobulin (B2M) and neuron-specific enolase (NSE) as prognostic factors in the population of patients over 65 years of age with frailty hospitalized due to… read more here.
Keywords: age frailty; syndrome; b2m; patients years ... See more keywords
Evaluation of serum interleukin 2 receptor and beta-2-microglobulin as prognostic factors for canine lymphoma: a pilot study.
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary and comparative oncology"
DOI: 10.1111/vco.12873
Abstract: Interleukin 2 receptor (IL-2R) is released from activated T cell lymphocytes and related to proliferation of B cells and T cells. Beta-2-microglobulin (B2M) is synthesized from all nucleated cells and constitutes a major histocompatibility complex… read more here.
Keywords: b2m; lymphoma; serum; canine lymphoma ... See more keywords
β2-microglobulin maintains glioblastoma stem cells and induces M2-like polarization of tumor-associated macrophages.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0507
Abstract: Glioblastoma (GBM) is a complex ecosystem that includes a heterogeneous tumor population and the tumor immune microenvironment (TIME), prominently containing tumor-associated macrophages (TAMs) and microglia. Here, we demonstrated that β2-microglobulin (B2M), a subunit of the… read more here.
Keywords: b2m; associated macrophages; stem; tumor ... See more keywords
Abstract 5195: BNDG B2m KO plus mouse model is a powerful tool for immunotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5195
Abstract: The B-NDG (Biocyotgen; NOD; DNAPK null; IL2rg knockout) mouse model was developed to be an ideal testing platform for anti-tumor therapies in Cell-Line and Patient Derived Xenograft Models (CDX and PDX respectively). B-NDG mice exhibit… read more here.
Keywords: b2m; plus mice; ndg b2m; model ... See more keywords
Identification of a Novel Function of B2M Involving T-Cell Exhaustion Via P-Selectin Ligand Upregulation in Diffuse Large B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-202199
Abstract: Background: Despite improvement of outcomes with current immuno-chemotherapies, approximately 40% of diffuse large B-cell lymphoma (DLBCL) patients suffer from recurrence or relapse, making it a refractory lymphoma. We previously reported that down-regulation of major histocompatibility… read more here.
Keywords: dlbcl; selplg; selectin; cell ... See more keywords
Knockout of the Beta-2 Microglobulin Gene in Adipose Tissue-Derived Cells Using CRISPR/CAS9 System for the Generation of Universal HLA Class I Platelets
Sign Up to like & getrecommendations! Published in 2024 at "Blood"
DOI: 10.1182/blood-2024-205233
Abstract: Platelet refractoriness is a recurring problem in the treatment of thrombocytopenic patients, hindering the restoration of normal circulating platelet levels after platelet transfusion therapy. The primary cause is the incompatibility between the transfused platelets' HLA… read more here.
Keywords: hla class; culture; class; b2m ... See more keywords
Donor natural killer cells trigger production of beta-2-microglobulin to enhance post bone marrow transplant immunity.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2021015297
Abstract: Allogeneic hematopoietic transplantation is a powerful treatment for hematologic malignancies. Post-transplant immune incompetence exposes patients to disease relapse and infections. We previously demostrated that donor alloreactive natural killer (NK) cells ablate recipient hematopoietic targets, including… read more here.
Keywords: b2m; alloreactive cells; natural killer; killer cells ... See more keywords