Knocking down B7H3 expression enhances cell proliferation of SHEDs via the SHP1/AKT signal axis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.154
Abstract: B7H3 is a member of B7 family of immunoregulatory transmembrane glycoproteins associated with maintaining immune tolerance, tumor cell proliferation, migration, invasion and metabolism, drug resistance, and stem cell differentiation. Neural crest-derived Multipotent Stem Cells (MSCs)… read more here.
Keywords: b7h3; b7h3 expression; shp1 akt; expression ... See more keywords
Engineered oncolytic virus expressing B7H3-targeting BiTE enhances antitumor T-cell immune response
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-009901
Abstract: Background Bispecific T-cell engagers (BiTEs) are recombinant bispecific proteins designed to stimulate polyclonal T-cell immunity. In recent years, B7H3, a pan-cancer antigen, has been considered a promising target for future immunotherapy. However, the B7H3-targeting BiTE… read more here.
Keywords: b7h3 bite; b7h3; targeting bite; cell ... See more keywords
Abstract 4080: IBB0979, A novel B7H3/IL-10 immunocytokine of monovalent anti-B7H3 antibody fused with IL-10 homodimer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-4080
Abstract: Background: This study demonstrates the preclinical evaluation of a novel B7H3/IL-10 immunocytokine IBB0979. IBB0979 was designed to solve the problems of immune cell exhaustion and drug resistance in current immunotherapy. As the tumors progress, the… read more here.
Keywords: novel b7h3; b7h3; ibb0979; b7h3 antibody ... See more keywords
Abstract 5731: BGB-C354, a novel B7H3 ADC with high DAR stability and strong bystander effect, demonstrates robust antitumor activity in preclinical models
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5731
Abstract: B7H3 is a type I transmembrane protein belonging to the B7 immunoregulatory family. B7H3 is overexpressed on a wide range of solid tumors such as lung cancers, gastrointestinal cancers and gynecological cancers, but its expression… read more here.
Keywords: bgb c354; dar; b7h3; activity ... See more keywords
Abstract CT121: A phase 1/2a, multicenter, open-label, first in human study of a bispecific ADC targeting B7H3 and PDL1 (DB-1419) in advanced or metastatic solid tumors
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-ct121
Abstract: Both B7H3 and PD-(L)1 are highly expressed in various solid tumors, including lung cancer, hepatocellular cancer, breast cancer, melanoma, and many others. Dual blockade of B7H3 and PD-(L)1 improved antitumor activity compared to either agent… read more here.
Keywords: cancer; metastatic solid; solid tumors; b7h3 ... See more keywords
A phase 1 study of B7H3 CAR-T cells administered intracranially in recurrent glioblastoma.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.2018
Abstract: 2018 Background: Glioblastoma (GBM) is an aggressive malignancy with median survival of approximately 2 years from initial diagnosis and 9 months after first progression. Effective treatments in the recurrent setting following upfront chemoradiation and adjuvant… read more here.
Keywords: b7h3 cart; phase study; b7h3; glioblastoma ... See more keywords
Effect of chemotherapy drug cisplatin on the efficacy of B7H3 CAR-T cells in treating melanoma by increasing target antigen density.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.e21562
Abstract: e21562 Background: B7H3 is overexpressed in multiple types of solid tumors, including melanoma, making it an ideal target for chimeric antigen receptor (CAR)-T cell therapy. However, the efficacy of B7H3 CAR-T cell therapies in solid… read more here.
Keywords: low dose; cisplatin; b7h3; car ... See more keywords
B7H3 As a Promoter of Metastasis and Promising Therapeutic Target
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2018.00264
Abstract: B7H3 (also known as CD276, an immune checkpoint molecule) is aberrantly overexpressed in many types of cancer, and such upregulation is generally associated with a poor clinical prognosis. Recent discoveries indicate a crucial role for… read more here.
Keywords: b7h3; b7h3 promoter; metastasis; cancer ... See more keywords
B7H3 Immune Checkpoint Overexpression Is Associated with Decreased Complete Response Rates to Neoadjuvant Therapy in Locally Advanced Rectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Diagnostics"
DOI: 10.3390/diagnostics14182023
Abstract: Background and Objectives: Rectal cancer accounts for approximately one-third of colorectal cancers, with over 340,000 deaths globally in 2022. Despite advancements in treatment, the five-year overall survival for locally advanced rectal cancer (LARC) remains at… read more here.
Keywords: b7h3 expression; therapy; b7h3; rectal cancer ... See more keywords