Evaluation of the anticancer activity of enzymatically synthesized Baccatin III: an intermediate precursor of Taxol®
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DOI: 10.1007/s13205-020-02457-1
Abstract: Baccatin III is an important precursor for the synthesis of clinically important anticancer drug Taxol. Previously, we have characterized a key enzyme of 10-deacetylbaccatin III-10-β-O-acetyltransferase (DBAT) which catalyses the 10-deacetylbaccatin III into baccatin III in… read more here.
Keywords: iii; synthesized baccatin; enzymatically synthesized; cancer ... See more keywords
Construction of acetyl-CoA and DBAT hybrid metabolic pathway for acetylation of 10-deacetylbaccatin III to baccatin III
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DOI: 10.1016/j.apsb.2021.03.029
Abstract: Abstract 10-Deacetylbaccatin III (10-DAB) C10 acetylation is an indispensable procedure for Taxol semi-synthesis, which often requires harsh conditions. 10-Deacetylbaccatin III-10-β-O-acetyltransferase (DBAT) catalyzes the acetylation but acetyl-CoA supply remains a key limiting factor. Here we refactored… read more here.
Keywords: iii; acetyl coa; baccatin iii;