Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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DOI: 10.1126/sciadv.abo3610
Abstract: Abnormal accumulation of β-amyloid (Aβ) peptides is a culprit in Alzheimer’s disease (AD); blocking Aβ generation is therefore being explored as a logical approach for AD treatment. Here, we demonstrate that targeted inhibition of β-site… read more here.
Keywords: clearance; bace; inhibition; bace microglia ... See more keywords