Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c07241
Abstract: Tangeretin (TAN) exhibits many bioactivities, including neuroprotective effects. However, the efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In the present study, we integrated behavioral tests, pathology assessment, and biochemical analyses… read more here.
Keywords: activity attenuates; inhibits bace1; pathology; activity ... See more keywords
Membrane-Targeted Quantum Dot-Based BACE1 Activity Sensors for In Vitro and In Cellulo Assays
Sign Up to like & getrecommendations! Published in 2024 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.4c12560
Abstract: The need for the development of specific and robust methodologies to elucidate the intricate pathological mechanisms of neurodegenerative diseases and discover effective treatments for prevention and remediation is evident. Alzheimer’s disease, in particular, has become… read more here.
Keywords: quantum dot; bace1 activity; membrane targeted; activity ... See more keywords
Increased Serum Beta-Secretase 1 Activity is an Early Marker of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Alzheimer's Disease"
DOI: 10.3233/jad-215542
Abstract: Background: Beta-site APP cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid-β (Aβ) plaques formation. BACE1 activity is increased in brains of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and plasma… read more here.
Keywords: alzheimer disease; activity; bace1 activity; activity early ... See more keywords
Serum Beta-Secretase 1 Activity Is a Potential Marker for the Differential Diagnosis between Alzheimer’s Disease and Frontotemporal Dementia: A Pilot Study
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms25158354
Abstract: Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are the two major neurodegenerative diseases causing dementia. Due to similar clinical phenotypes, differential diagnosis is challenging without specific biomarkers. Beta-site Amyloid Precursor Protein cleaving enzyme 1 (BACE1)… read more here.
Keywords: differential diagnosis; bace1 activity; dementia; activity ... See more keywords
Caesalpinia mimosoides Leaf Extract Promotes Neurite Outgrowth and Inhibits BACE1 Activity in Mutant APP-Overexpressing Neuronal Neuro2a Cells
Sign Up to like & getrecommendations! Published in 2021 at "Pharmaceuticals"
DOI: 10.3390/ph14090901
Abstract: Alzheimer’s disease (AD) is implicated in the imbalance of several proteins, including Amyloid-β (Aβ), amyloid precursor protein (APP), and BACE1. APP overexpression interferes with neurite outgrowth, while BACE1 plays a role in Aβ generation. Medicinal… read more here.
Keywords: bace1 activity; neurite outgrowth; app overexpressing; outgrowth ... See more keywords