BACE1 inhibitors: Current status and future directions in treating Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21622
Abstract: Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative brain disorder with no current cure. One of the important therapeutic approaches of AD is the inhibition of β‐site APP cleaving enzyme‐1 (BACE1), which is involved in… read more here.
Keywords: bace1 inhibitors; alzheimer disease; treating alzheimer; inhibitors current ... See more keywords
Flavonoids as BACE1 inhibitors: QSAR modelling, screening and in vitro evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.09.232
Abstract: Alzheimer's disease (AD) is marked by the presence of amyloid plaques, neurofibrillary tangles, oxidatively damaged neuronal macromolecules and redox sensitive ions. Reduction of amyloid plaques and oxidative stress emerge as a convincing treatment strategy. Plaque… read more here.
Keywords: bace1 inhibitors; modelling screening; flavonoids bace1; inhibitors qsar ... See more keywords
Computational analysis of BACE1-ligand complex crystal structures and linear discriminant analysis for identification of BACE1 inhibitors with anti P-glycoprotein binding property
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2016.1276477
Abstract: More than 100 years of research on Alzheimer’s disease didn’t yield a potential cure for this dreadful disease. Poor Blood Brain Barrier (BBB) permeability and P-glycoprotein binding of BACE1 inhibitors are the major causes for… read more here.
Keywords: bace1 inhibitors; bace1 ligand; analysis; glycoprotein binding ... See more keywords
Drug Discovery To Drug Development Of Bace1 Inhibitor As Anti-Alzheimers's: A Review.
Sign Up to like & getrecommendations! Published in 2022 at "Current topics in medicinal chemistry"
DOI: 10.2174/1568026623666221228140450
Abstract: Alzheimer's Disease (AD) is a complex and progressive neurodegenerative disease, and the most common cause of dementia usually occurs due to old age. Production and accumulation of amyloid-β peptide (Aβ) represent the major pathological event… read more here.
Keywords: bace1 inhibitors; disease; development; inhibitor ... See more keywords
Structure-Based Design of Selective beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: Targeting the Flap to Gain Selectivity over BACE2.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.2210/pdb6jse/pdb
Abstract: BACE1 inhibitors hold potential as agents in disease-modifying treatment for Alzheimer’s disease. BACE2 cleaves the melanocyte protein PMEL in pigment cells of the skin and eye, generating melanin pigments. This role of BACE2 implies that… read more here.
Keywords: bace2; bace1; structure based; bace1 inhibitors ... See more keywords
BACE1 Inhibitors for Alzheimer’s Disease: The Past, Present and Any Future?
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27248823
Abstract: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder and the most common cause of dementia in the elderly. The complexity of AD has hindered the development of either a cure or a disease-modifying therapy… read more here.
Keywords: bace1 inhibitors; disease; alzheimer disease; inhibitors alzheimer ... See more keywords