The Cys‐Pro motifs in the intrinsically disordered regions of the transcription factor BACH1 mediate distinct and overlapping functions upon heme binding
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14338
Abstract: The function of the transcription factor BACH1 is regulated by heme binding to multiple Cys‐Pro (CP) motifs within its intrinsically disordered regions. Here, biochemical analyses were conducted to reveal the individual functional roles of the… read more here.
Keywords: cys pro; heme; heme binding; factor bach1 ... See more keywords
Proteomic analysis of the IPF mesenchymal progenitor cell nuclear proteome identifies abnormalities in key nodal proteins that underlie their fibrogenic phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Proteomics"
DOI: 10.1002/pmic.202200018
Abstract: IPF is a progressive fibrotic lung disease whose pathogenesis remains incompletely understood. We have previously discovered pathologic mesenchymal progenitor cells (MPCs) in the lungs of IPF patients. IPF MPCs display a distinct transcriptome and create… read more here.
Keywords: ipf; phenotype; progenitor; mesenchymal progenitor ... See more keywords
Bach1-induced suppression of angiogenesis is dependent on the BTB domain
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.102617
Abstract: The transcription factor Bach1 impairs angiogenesis after ischemic injury by suppressing Wnt/β-catenin signaling; however, the specific domains responsible for the anti-angiogenic effects of Bach1 remain unclear. This study determined the role of the BTB domain… read more here.
Keywords: btb; angiogenesis; domain bach1; bach1 ... See more keywords
SanWeiGanJiang San relieves liver injury via Nrf2/Bach1.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2019.112445
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE San Wei Gan jiang San (SWGJS) also called Jia Ga Song Tang, is widely used in ancient medicine for liver diseases. THE AIM OF THIS STUDY To identify the blood components of SWGJS.… read more here.
Keywords: medicine; nrf2 bach1; bach1; liver injury ... See more keywords
The electrophilic character of quinones is essential for the suppression of Bach1.
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology"
DOI: 10.1016/j.tox.2017.06.006
Abstract: The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is the most important cellular defense mechanisms against oxidative attack. BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a… read more here.
Keywords: electrophilic character; quinones essential; essential suppression; character quinones ... See more keywords
Bach1 derepression is neuroprotective in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111643118
Abstract: Significance The Keap1-Nrf2 signaling pathway is a promising therapeutic target for Parkinson’s disease (PD). Canonical Nrf2 activators targeting Keap1 thiols are known to be preventive but never effectively cure chronic neurodegeneration because of their electrophilic… read more here.
Keywords: inhibitor; promising therapeutic; bach1; parkinson disease ... See more keywords
BACH1 recruits NANOG and histone H3 lysine 4 methyltransferase MLL/SET1 complexes to regulate enhancer–promoter activity and maintains pluripotency
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab034
Abstract: Abstract Maintenance of stem-cell identity requires proper regulation of enhancer activity. Both transcription factors OCT4/SOX2/NANOG and histone methyltransferase complexes MLL/SET1 were shown to regulate enhancer activity, but how they are regulated in embryonic stem cells… read more here.
Keywords: enhancer promoter; set1 complexes; maintains pluripotency; mll set1 ... See more keywords
BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad120
Abstract: Abstract The transcription factor BTB and CNC homology 1(BACH1) has been linked to coronary artery disease risk by human genome-wide association studies, but little is known about the role of BACH1 in vascular smooth muscle… read more here.
Keywords: chromatin accessibility; vascular smooth; bach1; smooth muscle ... See more keywords
Bach1 modulates AKT3 transcription to participate in hyperglycaemia‐mediated EndMT in vascular endothelial cells
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DOI: 10.1111/1440-1681.13759
Abstract: Hyperglycaemia‐mediated endothelial‐to‐mesenchymal transition (EndMT) is involved in the occurrence and progression of cardiovascular complications in diabetic patients. Previous studies reported that AKT serine/threonine kinase 3 (AKT3) and Bric‐a‐brac/Tramtrack/Broad (BTB) and cap'n'collar (CNC) homology 1 (bach1)… read more here.
Keywords: akt3 transcription; high glucose; bach1; hyperglycaemia ... See more keywords
BACH1 promotes clear cell renal cell carcinoma progression by upregulating oxidative stress‐related tumorigenicity
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DOI: 10.1111/cas.15607
Abstract: The carcinogenesis and progression of renal cell carcinoma (RCC), a heterogeneous cancer derived from renal tubular epithelial cells, is closely related to oxidative stress responses (OSRs). Oxidative stress responses participate in various biological processes related… read more here.
Keywords: cell; renal cell; progression; oxidative stress ... See more keywords
BACH1 promotes pancreatic cancer metastasis by repressing epithelial genes and enhancing epithelial-mesenchymal transition.
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DOI: 10.1158/0008-5472.can-18-4099
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the poorest prognoses due to its highly malignant features. BTB and CNC homology 1 (BACH1) has been implicated in RAS-driven tumor formation. We focused on the… read more here.
Keywords: expression; cancer; epithelial mesenchymal; bach1 ... See more keywords