Super‐killer CTLs are generated by single gene deletion of Bach2
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202249797
Abstract: Bach2 codes for a transcriptional regulator exerting major influences on T cell‐mediated immune regulation. Effector CTLs derived from in vitro activation of murine CD8+ T cells showed increased proliferative and cytolytic capacity in the absence… read more here.
Keywords: ctls; bach2; super killer; gene deletion ... See more keywords
HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
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DOI: 10.1038/s41467-017-00609-1
Abstract: HIV-1 insertions targeting BACH2 or MLK2 are enriched and persist for decades in hematopoietic cells from patients under combination antiretroviral therapy. However, it is unclear how these insertions provide such selective advantage to infected cell… read more here.
Keywords: bach2; stat5b; regulatory cells; mediated insertional ... See more keywords
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis
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DOI: 10.1038/s41467-019-14112-2
Abstract: Differentiation and homeostasis of Foxp3 + regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms that govern these processes are incompletely understood. Here we show that Bach2 is an… read more here.
Keywords: homeostasis; bach2; cell differentiation; differentiation ... See more keywords
Exploring novel functions of BACH2 in the acquisition of antigen-specific antibodies.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac065
Abstract: BACH2 [BTB (broad-complex, tramtrak and bric à brac) and CNC (cap 'n' collar) homolog 2] is known as a transcriptional repressor and broadly functions in regulating immune cell differentiation. Here, we focus on BACH2 function… read more here.
Keywords: novel functions; bach2 acquisition; acquisition antigen; bach2 ... See more keywords
Frequent downregulation of BTB and CNC homology 2 expression in Epstein–Barr virus‐positive diffuse large B‐cell lymphoma
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DOI: 10.1111/cas.13213
Abstract: Diffuse large B‐cell lymphoma (DLBCL) is the most common B‐cell lymphoma subtype, and the Epstein–Barr virus (EBV)‐positive subtype of DLBCL is known to show a more aggressive clinical behavior than the EBV‐negative one. BTB and… read more here.
Keywords: downregulation; bach2; ebv positive; cell lymphoma ... See more keywords
Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/2814510
Abstract: Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic dermatitis. Emerging… read more here.
Keywords: cell; th2 immune; immune response; bach2 ... See more keywords
BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/6789055
Abstract: FoxP3+ regulatory T cells (Tregs) are essential for self-tolerance and moderating tissue-damaging inflammation. Tregs that develop and mature in the thymus are classified as central Tregs or effector Tregs based on whether Tregs predominately inhabit… read more here.
Keywords: regulatory cells; adipose tissue; bach2; restrains type ... See more keywords
The role behind the scenes of Tregs and Th17s in Hashimoto’s thyroiditis: Toward a pivotal role of FOXP3 and BACH2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1098243
Abstract: In Hashimoto’s thyroiditis (HT), the genetic bases play a central role in determining development of the disease. In particular, the most frequent genes involved in the onset of HT are the Human Leukocyte Antigen (HLA).… read more here.
Keywords: role; hashimoto thyroiditis; bach2; role behind ... See more keywords
The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function
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DOI: 10.7554/elife.77294
Abstract: BTB domain And CNC Homolog 2 (Bach2) is a transcription repressor that actively participates in T and B lymphocyte development, but it is unknown if Bach2 is also involved in the development of innate immune… read more here.
Keywords: cell; maturation; transcription; natural killer ... See more keywords
HIV-1 promoter is gradually silenced when integrated into BACH2 in Jurkat T-cells
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DOI: 10.7717/peerj.10321
Abstract: Background The persistence of the latent HIV-1 reservoir is a major obstacle to curing HIV-1 infection. HIV-1 integrates into the cellular genome and some targeted genomic loci are frequently detected in clonally expanded latently HIV-1… read more here.
Keywords: jurkat cells; bach2 jurkat; bach2; hiv promoter ... See more keywords