Nucleobase Modified Adefovir (PMEA) Analogues as Potent and Selective Inhibitors of Adenylate Cyclases from Bordetella pertussis and Bacillus anthracis
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800332
Abstract: A series of 13 acyclic nucleoside phosphonates (ANPs) as bisamidate prodrugs was prepared. Five compounds were found to be non‐cytotoxic and selective inhibitors of Bordetella pertussis adenylate cyclase toxin (ACT) in J774A.1 macrophage cell‐based assays.… read more here.
Keywords: potent selective; adenylate cyclases; bacillus anthracis; bordetella pertussis ... See more keywords
Genome sequence of Bacillus anthracis typing phage AP631
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-04135-3
Abstract: AP631, a virulent bacteriophage of Bacillus anthracis, is widely used in China to identify anthrax bacteria. In this study, we report the complete AP631 phage genome sequence as well as comparative genomic analysis with other… read more here.
Keywords: phage ap631; phage; bacillus anthracis; genome sequence ... See more keywords
Structural and Functional Properties of Exopolysaccharide Excreted by a Novel Bacillus anthracis (Strain PFAB2) of Hot Spring Origin
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DOI: 10.1007/s12088-017-0699-4
Abstract: Exopolysaccharide produced by a unique avirulent Bacillus anthracis strain PFAB2 of hot spring origin has been characterized and its functional properties are investigated which is a first report. Maximum yield of EPS is 7.66 g/l with… read more here.
Keywords: hot spring; strain pfab2; anthracis strain; bacillus anthracis ... See more keywords
ClpC-Mediated Sporulation Regulation at Engulfment Stage in Bacillus anthracis.
Sign Up to like & getrecommendations! Published in 2021 at "Indian journal of microbiology"
DOI: 10.1007/s12088-021-00927-5
Abstract: Bacterial sporulation is a conserved process utilized by members of Bacillus genus and Clostridium in response to stress such as nutrient or temperature. Sporulation initiation is triggered by stress signals perceived by bacterial cell that… read more here.
Keywords: sporulation; engulfment; bacillus anthracis; clpc mediated ... See more keywords
Development of a set of three real-time loop-mediated isothermal amplification (LAMP) assays for detection of Bacillus anthracis, the causative agent of anthrax.
Sign Up to like & getrecommendations! Published in 2021 at "Folia microbiologica"
DOI: 10.1007/s12223-021-00869-x
Abstract: Bacillus anthracis, the causative agent of anthrax is a Gram-positive, non-motile, spore forming bacterium. Its spores can persist in soil and water for years and can also be aerosolized. A rapid, sensitive and specific method… read more here.
Keywords: causative agent; bacillus anthracis; anthrax; amplification ... See more keywords
Rapid identification of Bacillus anthracis by real-time PCR with dual hybridization probes in environmental swabs.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and cellular probes"
DOI: 10.1016/j.mcp.2017.11.001
Abstract: In the present study, we report the development of a real-time PCR assay for the identification of Bacillus anthracis, based on the amplification of a unique chromosomal marker, the E4 sequence, with dual hybridization probes.… read more here.
Keywords: time pcr; identification bacillus; bacillus anthracis; real time ... See more keywords
Crp/fnr family protein binds to promoters of atxA and sodmn genes that regulate the expression of exotoxins in Bacillus anthracis.
Sign Up to like & getrecommendations! Published in 2022 at "Protein expression and purification"
DOI: 10.1016/j.pep.2022.106059
Abstract: Bacillus anthracis produces a tripartite exotoxin, which is regulated by AtxA. Sodmn is constitutively expressed during invasion. Crp/Fnr family transcriptional regulators are known to bind promoters of toxin regulators as well as constitutively expressed genes… read more here.
Keywords: expression; atxa sodmn; bacillus anthracis; fnr family ... See more keywords
Effect of Phosphate Ion on the Structure of Lumazine Synthase, an Antigen Presentation System From Bacillus anthracis.
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DOI: 10.1016/j.xphs.2017.10.013
Abstract: Lumazine synthase (LS) is an oligomeric enzyme involved in the biosynthesis of riboflavin in microorganisms, fungi, and plants. LS has become of significant interest to biomedical science because of its critical biological role and attractive… read more here.
Keywords: lumazine synthase; bacillus anthracis; antigen presentation; structure ... See more keywords
Phosphorylation-Dependent Effects on the Structural Flexibility of Phosphoglucosamine Mutase from Bacillus anthracis
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DOI: 10.1021/acsomega.7b01490
Abstract: Phosphoglucosamine mutase (PNGM) is an evolutionarily conserved bacterial enzyme in the peptidoglycan biosynthetic pathway, catalyzing the reversible conversion between glucosamine 1- and 6-phosphate. Previous structural studies of PNGM from the pathogen Bacillus anthracis revealed its… read more here.
Keywords: bacillus anthracis; flexibility; phosphorylation dependent; phosphoglucosamine mutase ... See more keywords
An RNA-binding protein acts as a major post-transcriptional modulator in Bacillus anthracis.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29209-4
Abstract: HitRS is a two-component system that responds to cell envelope damage in the human pathogen Bacillus anthracis. Here we identify an RNA-binding protein, KrrA, that regulates HitRS function by modulating the stability of the hitRS… read more here.
Keywords: rna binding; bacillus anthracis; binding protein; protein acts ... See more keywords
Modeling on the Effects of Deliberate Release of Aerosolized Inhalational Bacillus anthracis (Anthrax) on an Australian Population.
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DOI: 10.1089/hs.2022.0100
Abstract: This study aimed to determine optimal mitigation strategies in the event of an aerosolized attack with Bacillus anthracis, a category A bioterrorism agent with a case fatality rate of nearly 100% if inhaled and untreated.… read more here.
Keywords: bacillus; deliberate release; modeling effects; effects deliberate ... See more keywords