Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc06936e
Abstract: Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a… read more here.
Keywords: mismatch binding; splicing reaction; rna; circular rna ... See more keywords
Deep learning of the back-splicing code for circular RNA formation
Sign Up to like & getrecommendations! Published in 2019 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btz382
Abstract: MOTIVATION Circular RNAs (circRNAs) are a new class of endogenous RNAs in animals and plants. During pre-RNA splicing, the 5' and 3' termini of exon(s) can be covalently ligated to form circRNAs through back-splicing (head-to-tail… read more here.
Keywords: rna; deep learning; formation; back splicing ... See more keywords
Comprehensive identification of alternative back-splicing in human tissue transcriptomes
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa005
Abstract: Abstract Circular RNAs (circRNAs) are covalently closed RNAs derived from back-splicing of genes across eukaryotes. Through alternative back-splicing (ABS), a single gene produces multiple circRNAs sharing the same back-splice site. Although many ABS events have… read more here.
Keywords: human tissue; alternative back; back splicing; tissue transcriptomes ... See more keywords
Sex-lethal regulates back-splicing and generation of the sex-differentially expressed circular RNAs.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad280
Abstract: Abstract Conversely to canonical splicing, back-splicing connects the upstream 3' splice site (SS) with a downstream 5'SS and generates exonic circular RNAs (circRNAs) that are widely identified and have regulatory functions in eukaryotic gene expression.… read more here.
Keywords: sxl; sex differentially; circular rnas; sex lethal ... See more keywords
Human Papillomavirus Type 16 Circular RNA Is Barely Detectable for the Claimed Biological Activity
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DOI: 10.1128/mbio.03594-21
Abstract: RNA back-splicing is a rare splicing event accounting for read more here.
Keywords: back splicing; caski cells; circe7; cell ... See more keywords