Divergent Supramolecular Gelation of Backbone Modified Short Hybrid δ-Peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01684
Abstract: The ordered supramolecular assemblies of short peptides have been recently gaining momentum due to their widespread applications in biology and materials sciences. In contrast to the α-peptides, limited success has been achieved from the backbone… read more here.
Keywords: gelation; short hybrid; backbone; backbone modified ... See more keywords
Redirecting RiPP Biosynthetic Enzymes to Proteins and Backbone-Modified Substrates
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1021/acscentsci.1c01577
Abstract: Ribosomally synthesized and post-translationally modified peptides (RiPPs) are peptide-derived natural products that include the FDA-approved analgesic ziconotide1,2 as well as compounds with potent antibiotic, antiviral, and anticancer properties.3 RiPP enzymes known as cyclodehydratases and dehydrogenases… read more here.
Keywords: backbone modified; biosynthetic enzymes; enzymes proteins; redirecting ripp ... See more keywords
Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs.
Sign Up to like & getrecommendations! Published in 2020 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.0c00232
Abstract: Two unsymmetrical dinucleotide phosphate triesters were synthesized via transesterification from tris(2,2,2-trifluoroethyl) phosphate. The protected triesters were phosphytilated to generate phosphoramidites for solid-phase oligonucleotide synthesis. Neutral phenylethyl phosphate-modified short-interfering RNAs (siRNAs) were synthesized and evaluated for… read more here.
Keywords: phosphate triester; synthesis evaluation; backbone modified; phosphate ... See more keywords