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   Articles with "backbone resonance" as a keyword



Backbone resonance assignments of monomeric SOD1 in dilute and crowded environments

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recommendations! Published in 2017 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-016-9724-5

Abstract: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that leads to movement disorders. In motor neurons of ALS patients, intracellular aggregates of superoxide dismutase 1 (SOD1) have often been observed. To elucidate the aggregation… read more here.

Keywords: protein; backbone resonance; sod1; monomeric sod1 ... See more keywords

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor

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recommendations! Published in 2017 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-017-9753-8

Abstract: NSD3 is a histone H3 methyltransferase that plays an important role in chromatin biology. A construct containing the methyltransferase domain encompassing residues Q1049-K1299 of human NSD3 was obtained and biochemical activity was demonstrated using histone… read more here.

Keywords: backbone resonance; resonance assignments; methyltransferase; nsd3 ... See more keywords

1H, 15N, 13C backbone resonance assignment of the C-terminal domain of enzyme I from Thermoanaerobacter tengcongensis

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recommendations! Published in 2018 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-017-9788-x

Abstract: Phosphoenolpyruvate binding to the C-terminal domain (EIC) of enzyme I of the bacterial phosphotransferase system (PTS) initiates a phosphorylation cascade that results in sugar translocation across the cell membrane and controls a large number of… read more here.

Keywords: backbone resonance; terminal domain; thermoanaerobacter tengcongensis; 15n 13c ... See more keywords

1H, 15N, 13C backbone resonance assignment of human Alkbh5

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recommendations! Published in 2018 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-018-9826-3

Abstract: N6-methyladenosine (m6A) is the most abundant and reversible post-transcriptional modification in eukaryotic mRNA and long non-coding RNA (lncRNA). The central role of m6A in various physiological processes has generated considerable biological and pharmacological interest. Alkbh5… read more here.

Keywords: backbone resonance; human alkbh5; assignment; 15n 13c ... See more keywords

Backbone resonance assignment for the N-terminal region of bacterial tRNA-(N1G37) methyltransferase

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recommendations! Published in 2019 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-018-9849-9

Abstract: Bacterial tRNA (guanine37-N1)-methyltransferase (TrmD) is an important antibacterial target due to its essential role in translation. TrmD has two domains connected with a flexible linker. The N-terminal domain (NTD) of TrmD contains the S-adenosyl-l-methionine (SAM)… read more here.

Keywords: backbone resonance; methyltransferase; trna; resonance assignment ... See more keywords

Backbone resonance assignments and secondary structure of Ebola nucleoprotein 600–739 construct

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recommendations! Published in 2019 at "Biomolecular NMR Assignments"

DOI: 10.1007/s12104-019-09898-7

Abstract: Ebola viral infections have resulted in several deadly epidemics in recent years in West and Central Africa. Because only one of the seven proteins encoded by the viral genome possesses enzymatic activity, disruption of protein–protein… read more here.

Keywords: backbone resonance; resonance assignments; secondary structure; 600 739 ... See more keywords

1H, 15N and 13C backbone resonance assignments of the P146A variant of β-phosphoglucomutase from Lactococcus lactis in its substrate-free form

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recommendations! Published in 2019 at "Biomolecular Nmr Assignments"

DOI: 10.1007/s12104-019-09904-y

Abstract: β-Phosphoglucomutase (βPGM) is a magnesium-dependent phosphoryl transfer enzyme that catalyses the reversible isomerisation of β-glucose 1-phosphate and glucose 6-phosphate, via two phosphoryl transfer steps and a β-glucose 1,6-bisphosphate intermediate. Substrate-free βPGM is an essential component… read more here.

Keywords: backbone resonance; substrate free; 15n 13c; backbone ... See more keywords
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Backbone resonance assignment of the cAMP-binding domains of the protein kinase A regulatory subunit Iα.

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recommendations! Published in 2021 at "Biomolecular NMR assignments"

DOI: 10.1007/s12104-021-10033-8

Abstract: Protein kinase A (PKA) is the main receptor for the universal cAMP second messenger. PKA is a tetramer with two catalytic (C) and two regulatory (R) subunits, each including two tandem cAMP-binding domains, i.e. CBD-A… read more here.

Keywords: backbone resonance; camp; binding domains; camp binding ... See more keywords

Backbone resonance assignment of PDI b'xa' domain construct.

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recommendations! Published in 2021 at "Biomolecular NMR assignments"

DOI: 10.1007/s12104-021-10038-3

Abstract: Human protein disulfide isomerase (PDI), a protein containing 4 domains a, b, b', a', disordered x linker and C-terminus, plays critical roles in disulfide bond reactions and proper protein folding in the endoplasmic reticulum. The… read more here.

Keywords: backbone resonance; construct; domain; assignment pdi ... See more keywords

NMR 1H, 13C, 15N backbone resonance assignments of 14-3-3ζ binding region of human FOXO3a (residues 1-284)

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recommendations! Published in 2024 at "Biomolecular Nmr Assignments"

DOI: 10.1007/s12104-024-10200-7

Abstract: In tumors, mutation in Ras proteins stimulates a signaling cascade through phosphorylation. Downstream of the cascade, many transcription and translation factors are up- or down-regulated by phosphorylation, leading to cancer progression. This phosphorylation cascade is… read more here.

Keywords: phosphorylation; foxo3a residues; resonance assignments; backbone resonance ... See more keywords

1H, 13C and 15N backbone resonance assignment of the lytic polysaccharide monooxygenase LsAA9A from Lentinus similis

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recommendations! Published in 2025 at "Biomolecular Nmr Assignments"

DOI: 10.1007/s12104-025-10256-z

Abstract: Lytic polysaccharide monooxygenases (LPMOs) are mono-copper binding enzymes involved in the degradation of carbohydrates. The 25 kDa sized LPMO LsAA9A from the basidiomycete Lentinus similis is known to oxidate cellulose and cellooligomers at the C4… read more here.

Keywords: resonance assignment; lentinus similis; lytic polysaccharide; 15n backbone ... See more keywords