Deep Brain Stimulation and Intrathecal/Intraventricular Baclofen for Glutaric Aciduria Type 1: A Scoping Review, Individual Patient Data Analysis, and Clinical Trials Review.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of inherited metabolic disease"
DOI: 10.1002/jimd.12638
Abstract: Glutaric aciduria type 1 (GA1) is an autosomal recessive disease frequently leading to dystonia. Deep brain stimulation (DBS), intrathecal baclofen (ITB), and intraventricular baclofen (IVB) are the current interventional treatment options for refractory dystonia. We… read more here.
Keywords: clinical trials; deep brain; aciduria type; glutaric aciduria ... See more keywords
Risk of hospitalisation and death related to baclofen for alcohol use disorders: Comparison with nalmefene, acamprosate, and naltrexone in a cohort study of 165 334 patients between 2009 and 2015 in France
Sign Up to like & getrecommendations! Published in 2018 at "Pharmacoepidemiology and Drug Safety"
DOI: 10.1002/pds.4635
Abstract: Baclofen is widely used off‐label for alcohol use disorders (AUD) in France, despite its uncertain efficacy and safety, particularly at high doses. This study was designed to evaluate the safety of this off‐label use compared… read more here.
Keywords: baclofen; use disorders; use; alcohol use ... See more keywords
Effect of coadministration of the GABAB agonist baclofen and the 5-HT2C agonist Ro60-0175 on the expression of amphetamine-induced locomotor sensitization
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Brain Research"
DOI: 10.1007/s00221-019-05540-z
Abstract: GABAB and 5-HT2C agonists are effective in attenuating the behavioral effects of psychostimulants. However, they induce adverse side effects when used in high doses. The previous evidence has suggested that the 5HT2C receptor activation effect… read more here.
Keywords: baclofen; gabab; agonist; ro60 0175 ... See more keywords
Intrathecal Baclofen Trial Before Device Implantation: 12-Year Experience With Continuous Administration.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of physical medicine and rehabilitation"
DOI: 10.1016/j.apmr.2018.09.124
Abstract: OBJECTIVE To report our experience using continuous intrathecal baclofen (ITB) administration prior to a possible ITB device implantation. DESIGN Retrospective open label study. Mean duration of follow-up 64 months. SETTING Primary-care and referral center, ambulatory… read more here.
Keywords: administration; level; itb; implantation ... See more keywords
Title: Quantifying the change of spasticity after intrathecal baclofen administration: A descriptive retrospective analysis
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.06.010
Abstract: OBJECTIVES Exploratory research quantifying the change of spasticity among patients who underwent baclofen intrathecal drug delivery system (IDDS) implantation. PATIENTS AND METHODS 88 patients with a baclofen IDDS were identified. Patient characteristics, spasticity scores pre/post… read more here.
Keywords: baclofen; quantifying change; change spasticity; intrathecal baclofen ... See more keywords
Recurrent Episodes of Brief Global Amnesia Related to Intrathecal Baclofen Pump: Originally Mistaken for Psychogenic Nonepileptic Seizures.
Sign Up to like & getrecommendations! Published in 2017 at "Psychosomatics"
DOI: 10.1016/j.psym.2017.03.011
Abstract: Background: Baclofen is a GABA-B receptor agonist widely used for treatment of spasticity by intrathecal route when oral baclofen was ineffective or intolerable. Here we report a case of recurrent episodes of brief global amnesia… read more here.
Keywords: baclofen; intrathecal baclofen; baclofen pump; global amnesia ... See more keywords
Improved response after intrathecal administration of baclofen in a patient with impaired consciousness – A case study
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Physical and Rehabilitation Medicine"
DOI: 10.1016/j.rehab.2018.05.849
Abstract: Introduction/Background Disorders of consciousness present some of the most difficult diagnostic and therapeutic challenges in brain rehabilitation. Within the spectrum of these disorders, diagnosis remains clinical and depends on the response to various stimuli in… read more here.
Keywords: baclofen; response; case study; patient ... See more keywords
Trends in gabapentin and baclofen exposures reported to U.S. poison centers
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DOI: 10.1080/15563650.2019.1687902
Abstract: Abstract Context: Prescriptions for nonopioid pharmacological therapies such as gabapentin and baclofen have been increasing. While gabapentin and baclofen are less likely than opioids to result in fatal overdose, they are each associated with dependence,… read more here.
Keywords: baclofen; gabapentin baclofen; misuse; exposures increased ... See more keywords
Baclofen Combined With Psychosocial Care is Useful and Safe in Alcohol-Related Cirrhosis Patients: A Real-Life Multicenter Study.
Sign Up to like & getrecommendations! Published in 2022 at "Alcohol and alcoholism"
DOI: 10.1093/alcalc/agac065
Abstract: BACKGROUND Alcohol-related cirrhosis is a frequent and difficult-to-treat disease. Despite the low hepatic metabolism of baclofen, data on its use in this subgroup are scarce. The French multicenter Observatory of patients treated with Baclofen for… read more here.
Keywords: related cirrhosis; real life; alcohol related; alcohol ... See more keywords
A Review of Baclofen Overdoses in Australia: Calls to a Poisons Information Centre and a Case Series
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol and Alcoholism"
DOI: 10.1093/alcalc/agy082
Abstract: Aim to describe trends in baclofen reports to Australia's largest Poisons Information Centre (PIC) and present a case series detailing severity of overdoses. Short summary PBS data demonstrates baclofen use is increasing in Australia, while… read more here.
Keywords: baclofen; increase; case; toxicity ... See more keywords
Clinical Predictors of Response to Baclofen in the Treatment of Alcohol use Disorder: Results from the BacALD Trial.
Sign Up to like & getrecommendations! Published in 2019 at "Alcohol and alcoholism"
DOI: 10.1093/alcalc/agz026
Abstract: AIM To examine clinical predictors of treatment response to baclofen in patients with alcohol use disorder (AUD). METHODS Data from a randomised controlled trial (RCT) (N = 104), in which AUD patients received placebo or… read more here.
Keywords: baclofen; response; alcohol consumption; treatment ... See more keywords