Genetically Engineered Bacteria‐Derived Hydrogel Orchestrates T Cell Spatial Dynamics for Triple‐Negative Breast Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202511779
Abstract: Impaired spatial dynamics of T cells represent a major challenge to effective immunotherapy in triple‐negative breast cancer (TNBC). Here, a genetically engineered, bacteria‐derived hydrogel is presented that precisely orchestrates T cell activation, trafficking, and tumor… read more here.
Keywords: spatial dynamics; immunotherapy; negative breast; cell ... See more keywords
Rapid surface display of mRNA antigens by bacteria-derived outer membrane vesicles for a personalized tumor vaccine.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202109984
Abstract: Therapeutic mRNA vaccination is an attractive approach to trigger antitumor immunity. However, the mRNA delivery technology for customized tumor vaccine is still limited. Herein, we employed bacteria-derived outer membrane vesicles (OMVs) as an mRNA delivery… read more here.
Keywords: tumor; bacteria derived; tumor vaccine; derived outer ... See more keywords
Biosynthetic neoantigen displayed on bacteria derived vesicles elicit systemic antitumour immunity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12289
Abstract: Abstract Neoantigens derived from mutant proteins in tumour cells could elicit potent personalized anti‐tumour immunity. Nevertheless, the layout of vaccine vehicle and synthesis of neoantigen are pivotal for stimulating robust response. The power of synthetic… read more here.
Keywords: bacteria derived; neoantigen; bdvs neo; immunity ... See more keywords
H2S scavenger as a broad-spectrum strategy to deplete bacteria-derived H2S for antibacterial sensitization
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-53764-7
Abstract: Bacteria-derived H2S plays multifunctional protective roles against antibiotics insult, and the H2S biogenesis pathway is emerging as a viable target for the antibacterial adjuvant design. However, the development of a pan-inhibitor against H2S-synthesizing enzymes is… read more here.
Keywords: derived h2s; bacteria derived; strategy deplete; h2s scavenger ... See more keywords
Lactic acid bacteria derived extracellular vesicles: emerging bioactive nanoparticles in modulating host health
Sign Up to like & getrecommendations! Published in 2024 at "Gut Microbes"
DOI: 10.1080/19490976.2024.2427311
Abstract: ABSTRACT Lactic acid bacteria derived extracellular vesicles (LAB-EVs) are nano-sized and carry a variety of biological cargoes. LAB-EVs have proven to be potential mediators of intercellular communication, serving not only the parental bacteria but also… read more here.
Keywords: lab; derived extracellular; lactic acid; acid bacteria ... See more keywords
Comparative study of adjuvants for allergen-specific immunotherapy in a murine model.
Sign Up to like & getrecommendations! Published in 2018 at "Immunotherapy"
DOI: 10.2217/imt-2018-0072
Abstract: AIM To compare the immunological and clinical changes induced by allergen-specific immunotherapy (AIT) using different adjuvants. MATERIALS & METHODS Olea europaea pollen-sensitized mice were treated with olea plus aluminum hydroxide, calcium phosphate, monophosphoryl lipid A… read more here.
Keywords: allergen specific; immunotherapy; bacteria derived; comparative study ... See more keywords
Bacteria derived extracellular vesicles in the pathogenesis and treatment of gastrointestinal tumours
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1103446
Abstract: Extracellular vesicles are fundamentally significant in the communication between cells. Outer Membrane Vesicles(OMVs) are a special kind of EVs produced by Gram-negative bacteria, which are minute exosome-like particles budding from the outer membrane, which have… read more here.
Keywords: extracellular vesicles; bacteria derived; treatment gastrointestinal; vesicles pathogenesis ... See more keywords
Bacteria-derived chimeric toxins as potential anticancer agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.953678
Abstract: Cancer is one of the major causes of death globally, requiring everlasting efforts to develop novel, specific, effective, and safe treatment strategies. Despite advances in recent years, chemotherapy, as the primary treatment for cancer, still… read more here.
Keywords: chimeric toxins; bacteria derived; treatment; anticancer agents ... See more keywords
Methods for the Cost-Effective Production of Bacteria-Derived Double-Stranded RNA for in vitro Knockdown Studies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.836106
Abstract: RNA interference (RNAi) is a highly conserved pathway for the post-transcriptional regulation of gene expression. It has become a crucial tool in life science research, with promising potential for pest-management applications. To induce an RNAi… read more here.
Keywords: double stranded; cost effective; bacteria derived; rna ... See more keywords
Bacteria-Derived Extracellular Vesicles in Urine as a Novel Biomarker for Gastric Cancer: Integration of Liquid Biopsy and Metagenome Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13184687
Abstract: Simple Summary Gastric cancer shows an improved prognosis when diagnosed in its early stage. However, non-invasive diagnostic markers for gastric cancer known to date have poor clinical efficacies. Many studies have shown that gastric cancer… read more here.
Keywords: gastric cancer; bacteria derived; cancer; metagenome analysis ... See more keywords
Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094807
Abstract: Neurodegenerative protein conformational diseases are characterized by the misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria,… read more here.
Keywords: bacteria derived; derived protein; host protein; host ... See more keywords