Benzylaminoethylureido‐Tailed Benzenesulfonamides Show Potent Inhibitory Activity against Bacterial Carbonic Anhydrases
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DOI: 10.1002/cmdc.202000680
Abstract: A series of benzylaminoethylureido‐tailed benzenesulfonamides was analyzed for their inhibition potential against bacterial carbonic anhydrases (CAs) such as VhCA α, β, and γ from Vibrio cholerae, and BpsCA β and γ‐CAs from Burkholderia pseudomallei. Growing… read more here.
Keywords: tailed benzenesulfonamides; benzylaminoethylureido tailed; carbonic anhydrases; bacterial carbonic ... See more keywords
Inhibition studies of bacterial α-carbonic anhydrases with phenols
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DOI: 10.1080/14756366.2022.2038592
Abstract: Abstract The α-class carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogens Neisseria gonorrhoeae (NgCAα) and Vibrio cholerae (VchCAα) were investigated for their inhibition by a panel of phenols and phenolic acids. Mono-, di- and… read more here.
Keywords: inhibition; carbonic anhydrases; anhydrases phenols; bacterial carbonic ... See more keywords
Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases
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DOI: 10.1080/14756366.2022.2163243
Abstract: Abstract A small library of novel thiazolone-benzenesulphonamides has been prepared and evaluated for their ability to inhibit three human cytosolic carbonic anhydrases (hCA I, hCA II, and hCA VII) and three bacterial carbonic anhydrases (MscCAβ,… read more here.
Keywords: carbonic anhydrases; bacterial carbonic; hca; novel thiazolone ... See more keywords
Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance.
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DOI: 10.2174/1568026617666170104101058
Abstract: BACKGROUND Clinically used antibiotics act through one of these four mechanisms: cell wall biosynthesis inhibition, inhibition of protein biosynthesis, interference with DNA and RNA synthesis and the folate pathway. OBJECTIVE The metalloenzymes carbonic anhydrases (CAs,… read more here.
Keywords: carbonic anhydrases; bacterial carbonic; inhibition; drug ... See more keywords